EIF2α activator 2

Modify Date: 2024-01-02 17:11:51

EIF2α activator 2 structure	Common Name	EIF2α activator 2
	CAS Number	1501618-04-7	Molecular Weight	446.39
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₂₀F₆N₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of EIF2α activator 2

EIF2α activator 2 (Compound 1) is an activator of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. EIF2α activator 2 exhibits high potency in SRB cell proliferation assays (IC50=0.46 μM). EIF2α activator 2 exhibits antiproliferative activity againist K562 and PBMC cells with IC50s of 4.79 and 10.52 μM, respectively[1].

Name	EIF2α activator 2

Description	EIF2α activator 2 (Compound 1) is an activator of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. EIF2α activator 2 exhibits high potency in SRB cell proliferation assays (IC50=0.46 μM). EIF2α activator 2 exhibits antiproliferative activity againist K562 and PBMC cells with IC50s of 4.79 and 10.52 μM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Eukaryotic Initiation Factor (eIF)
References	[1]. Jinsook Kwak, et al. A bioisosteric approach to the discovery of novel N-aryl-N'-[4-(aryloxy)cyclohexyl]squaramide-based activators of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. Eur J Med Chem. 2022 May 29;239:114501.

Molecular Formula	C₂₁H₂₀F₆N₂O₂
Molecular Weight	446.39

EIF2α activator 2

Use of EIF2α activator 2

Names

EIF2α activator 2 Biological Activity

Chemical & Physical Properties