EIF2α activator 2

Modify Date: 2025-08-25 14:38:58

EIF2α activator 2 Structure
EIF2α activator 2 structure
Common Name EIF2α activator 2
CAS Number 1501618-04-7 Molecular Weight 446.39
Density N/A Boiling Point N/A
Molecular Formula C21H20F6N2O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of EIF2α activator 2


EIF2α activator 2 (Compound 1) is an activator of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. EIF2α activator 2 exhibits high potency in SRB cell proliferation assays (IC50=0.46 μM). EIF2α activator 2 exhibits antiproliferative activity againist K562 and PBMC cells with IC50s of 4.79 and 10.52 μM, respectively[1].

 Names

Name EIF2α activator 2

 EIF2α activator 2 Biological Activity

Description EIF2α activator 2 (Compound 1) is an activator of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. EIF2α activator 2 exhibits high potency in SRB cell proliferation assays (IC50=0.46 μM). EIF2α activator 2 exhibits antiproliferative activity againist K562 and PBMC cells with IC50s of 4.79 and 10.52 μM, respectively[1].
Related Catalog
References

[1]. Jinsook Kwak, et al. A bioisosteric approach to the discovery of novel N-aryl-N'-[4-(aryloxy)cyclohexyl]squaramide-based activators of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. Eur J Med Chem. 2022 May 29;239:114501.

 Chemical & Physical Properties

Molecular Formula C21H20F6N2O2
Molecular Weight 446.39
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