Ketoprofen-13C,d3

Modify Date: 2024-01-08 17:24:31

Ketoprofen-13C,d3 structure	Common Name	Ketoprofen-13C,d3
	CAS Number	1189508-77-7	Molecular Weight	258.29
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅₁₃CH₁₁D₃O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Ketoprofen-13C,d3

Ketoprofen-13C,d3 is the 13C- and deuterium labeled. Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively[1].

Name	(2S)-2-(3-benzoylphenyl)-3,3,3-trideuteriopropanoic acid

Description	Ketoprofen-13C,d3 is the 13C- and deuterium labeled. Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[85].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [2]. Palomer A, et al. Structure-based design of cyclooxygenase-2 selectivity into ketoprofen. Bioorg Med Chem Lett. 2002 Feb 25;12(4):533-7. [3]. Negus SS, et al. Effects of ketoprofen, morphine, and kappa opioids on pain-related depression of nesting in mice. Pain. 2015 Jun;156(6):1153-60.

Molecular Formula	C₁₅₁₃CH₁₁D₃O₃
Molecular Weight	258.29
Exact Mass	258.11600
PSA	54.37000
LogP	3.10570

Ketoprofen-13C,d3

Use of Ketoprofen-13C,d3

Names

Ketoprofen-13C,d3 Biological Activity

Chemical & Physical Properties