ST-1006

Modify Date: 2024-01-02 13:08:49

ST-1006 Structure
ST-1006 structure
Common Name ST-1006
CAS Number 1196994-11-2 Molecular Weight 367.28
Density N/A Boiling Point N/A
Molecular Formula C16H20Cl2N6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ST-1006


ST-1006 is a potent histamine H4 receptor agonist with a pKi value of 7.94. ST-1006 has anti-inflammatory effect[1][2].

 Names

Name ST-1006

 ST-1006 Biological Activity

Description ST-1006 is a potent histamine H4 receptor agonist with a pKi value of 7.94. ST-1006 has anti-inflammatory effect[1][2].
Related Catalog
Target

H4 receptor:7.94 (pKi)

In Vitro ST-1006 (10 μM) 是一种有效的嗜碱性粒细胞迁移诱导剂,可诱导嗜碱性粒细胞迁移[2]。 ST-1006 (0-100 μM) 抑制 FceRI 介导的嗜碱性粒细胞激活并降低 FceRI 激活的嗜碱性粒细胞的 CD63 和 CD203c 表达水平[2]。
In Vivo ST-1006 (1-100 mg/kg;s.c.;雄性 CD-1 小鼠) 具有抗炎作用和止痒作用[1]。 Animal Model: Male CD-1 mice with pruritus (8-10 weeks and 25-30 g)[1] Dosage: 1-100 mg/kg Administration: Subcutaneous injection Result: Had an antipruritic effect at the non-anti-inflammatory dose of 30 mg/kg.
References

[1]. Adami M, et, al. Differential effects of functionally different histamine H4 receptor ligands on acute irritant dermatitis in mice. Naunyn Schmiedebergs Arch Pharmacol. 2018 Dec;391(12):1387-1397.  

[2]. Mommert S, et, al. Human basophil chemotaxis and activation are regulated via the histamine H4 receptor. Allergy. 2016 Sep;71(9):1264-73.  

 Chemical & Physical Properties

Molecular Formula C16H20Cl2N6
Molecular Weight 367.28
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