ST-1006

Modify Date: 2024-01-02 13:08:49

ST-1006 structure	Common Name	ST-1006
	CAS Number	1196994-11-2	Molecular Weight	367.28
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₂₀Cl₂N₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ST-1006

ST-1006 is a potent histamine H4 receptor agonist with a pKi value of 7.94. ST-1006 has anti-inflammatory effect[1][2].

Name	ST-1006

Description	ST-1006 is a potent histamine H4 receptor agonist with a pKi value of 7.94. ST-1006 has anti-inflammatory effect[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	H4 receptor:7.94 (pKi)
In Vitro	ST-1006 (10 μM) 是一种有效的嗜碱性粒细胞迁移诱导剂，可诱导嗜碱性粒细胞迁移[2]。 ST-1006 (0-100 μM) 抑制 FceRI 介导的嗜碱性粒细胞激活并降低 FceRI 激活的嗜碱性粒细胞的 CD63 和 CD203c 表达水平[2]。
In Vivo	ST-1006 (1-100 mg/kg；s.c.；雄性 CD-1 小鼠) 具有抗炎作用和止痒作用[1]。 Animal Model: Male CD-1 mice with pruritus (8-10 weeks and 25-30 g)[1] Dosage: 1-100 mg/kg Administration: Subcutaneous injection Result: Had an antipruritic effect at the non-anti-inflammatory dose of 30 mg/kg.
References	[1]. Adami M, et, al. Differential effects of functionally different histamine H4 receptor ligands on acute irritant dermatitis in mice. Naunyn Schmiedebergs Arch Pharmacol. 2018 Dec;391(12):1387-1397. [2]. Mommert S, et, al. Human basophil chemotaxis and activation are regulated via the histamine H4 receptor. Allergy. 2016 Sep;71(9):1264-73.

Molecular Formula	C₁₆H₂₀Cl₂N₆
Molecular Weight	367.28