Scoparone

Modify Date: 2025-08-25 23:08:41

Scoparone structure	Common Name	Scoparone
	CAS Number	120-08-1	Molecular Weight	206.195
	Density	1.2±0.1 g/cm3	Boiling Point	369.2±42.0 °C at 760 mmHg
	Molecular Formula	C₁₁H₁₀O₄	Melting Point	145°C
	MSDS	Chinese USA	Flash Point	166.8±27.9 °C
	Symbol	GHS06	Signal Word	Danger

Use of Scoparone

Scoparone is isolated from Artemisia capillaris, has anticoagulant, vasorelaxant antioxidant, anti-inflammatory activities[1].

Name	6,7-Dimethoxycoumarin
Synonym	More Synonyms

Description	Scoparone is isolated from Artemisia capillaris, has anticoagulant, vasorelaxant antioxidant, anti-inflammatory activities[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Scoparone (0-0.4 nM; 24-48 hours) produces the most inhibition on PSC proliferation at 0.4 nM[1].
In Vivo	Scoparone (oral administration; 30 mg/kg, 60 mg/kg; 4 weeks) greatly ameliorates the pancreatic weight loss induced by DBTC in pancreatitis rats[1]. Animal Model: Chronic Pancreatitis (CP) Rat Models[1] Dosage: 30 mg/kg, 60 mg/kg Administration: Oral administration; 30 mg/kg, 60 mg/kg; 4 weeks Result: Protected against pancreatic damage
References	[1]. Xu M, et al. Scoparone Protects Against Pancreatic Fibrosis via TGF-β/Smad Signaling in Rats. Cell Physiol Biochem. 2016;40(1-2):277-286. Epub 2016 Nov 18.

Density	1.2±0.1 g/cm3
Boiling Point	369.2±42.0 °C at 760 mmHg
Melting Point	145°C
Molecular Formula	C₁₁H₁₀O₄
Molecular Weight	206.195
Flash Point	166.8±27.9 °C
Exact Mass	206.057907
PSA	48.67000
LogP	1.60
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.557

Scoparone MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GN6550000

CHEMICAL NAME :: Coumarin, 6,7-dimethoxy-

CAS REGISTRY NUMBER :: 120-08-1

BEILSTEIN REFERENCE NO. :: 0169572

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C11-H10-O4

MOLECULAR WEIGHT :: 206.21

WISWESSER LINE NOTATION :: T66 BOVJ HO1 IO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 292 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 3,550,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 190 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 3,550,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 3,550,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - alteration of classical conditioning Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913- Volume(issue)/page/year: 60,763,1972 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1180 mg/kg

SEX/DURATION :: male 8 week(s) pre-mating female 2 week(s) pre-mating - 3 week(s) post-birth

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Effects on Newborn - delayed effects

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 17,740,1979

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 725 mg/kg

SEX/DURATION :: female 15-22 day(s) after conception lactating female 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 17,740,1979

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301-H319
Precautionary Statements	P301 + P310-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R23/24/25
Safety Phrases	S27/28-S36/37/39-S45-S26
RIDADR	2811
RTECS	GN6550000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2932209090

Precursor 9
CAS#:305-01-1 6,7-Dihydroxyco... CAS#:77-78-1 Dimethyl sulfate CAS#:74-88-4 methyl iodide CAS#:2033-89-8 3,4-Dimethoxyphenol
CAS#:15568-85-1 5-(Methoxymethy... CAS#:73490-50-3 Z-4,5-dimethoxy... CAS#:109300-68-7 2-(4,5-dimethox... CAS#:14382-91-3 2-hydroxy-4,5-d...
CAS#:1099-45-2 Ethyl 2-(triphe...
DownStream 5
CAS#:92-61-5 Scopoletin CAS#:24160-53-0 3-(2,4,5-Trimet... CAS#:114515-53-6 3-(2-hydroxy-4,... CAS#:56680-28-5 6,7-dimethoxy-3...
CAS#:581-31-7 Suberosin

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Green tea inhibited the elimination of nephro-cardiovascular toxins and deteriorated the renal function in rats with renal failure.

Sci. Rep. 5 , 16226, (2015)

Chronic kidney disease (CKD) is a major health problem worldwide. Indoxyl sulfate (IS) and p-cresyl sulfate (PCS) are highly protein-bound nephro-cardiovascular toxins, which are not efficiently remov...

7-substituted coumarins inhibit proliferation and migration of laryngeal cancer cells in vitro.

Anticancer Res. 33(10) , 4347-56, (2013)

Coumarins are a large group of naturally-occurring compounds with a wide range of biological properties, including anticancer activity. 7-Substituted coumarins (umbelliferone, scoparone, and herniarin...

Effects of scoparone on dopamine release in PC12 cells.

Fitoterapia 81(6) , 497-502, (2010)

The effects of scoparone on dopamine release in PC12 cells were investigated. Scoparone at 50-200 microM increased dopamine release into the culture medium. However, the released levels of dopamine by...

MFCD00006871

6,7-Dimethoxy-chromen-2-one

Scoparone

EINECS 204-369-0

Dimethylesculetin

6,7-dimethoxychromen-2-one

6,7-Dimethoxy-2H-chromen-2-one

2H-1-Benzopyran-2-one, 6,7-dimethoxy-

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Scoparone

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