6,7-Dihydroxycoumarin

Modify Date: 2024-01-02 17:41:39

6,7-Dihydroxycoumarin structure	Common Name	6,7-Dihydroxycoumarin
	CAS Number	305-01-1	Molecular Weight	178.141
	Density	1.6±0.1 g/cm3	Boiling Point	469.7±45.0 °C at 760 mmHg
	Molecular Formula	C₉H₆O₄	Melting Point	271-273 °C(lit.)
	MSDS	Chinese USA	Flash Point	201.5±22.2 °C
	Symbol	GHS07	Signal Word	Warning

Use of 6,7-Dihydroxycoumarin

Esculetin is an active ingredient extracted mainly from the bark of Fraxinus rhynchophylla. Esculetin inhibits platelet-derived growth factor (PDGF)-induced airway smooth muscle cells (ASMCs) phenotype switching through inhibition of PI3K/Akt pathway. Esculetin has antioxidant, antiinflammatory, and antitumor activities[1].

Name	esculetin
Synonym	More Synonyms

Description	Esculetin is an active ingredient extracted mainly from the bark of Fraxinus rhynchophylla. Esculetin inhibits platelet-derived growth factor (PDGF)-induced airway smooth muscle cells (ASMCs) phenotype switching through inhibition of PI3K/Akt pathway. Esculetin has antioxidant, antiinflammatory, and antitumor activities[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Signaling Pathways >> PI3K/Akt/mTOR >> Akt
Target	PI3K Akt
References	[1]. Xie C, et al. Esculetin regulates the phenotype switching of airway smooth muscle cells. Phytother Res. 2019 Aug 21.

Density	1.6±0.1 g/cm3
Boiling Point	469.7±45.0 °C at 760 mmHg
Melting Point	271-273 °C(lit.)
Molecular Formula	C₉H₆O₄
Molecular Weight	178.141
Flash Point	201.5±22.2 °C
Exact Mass	178.026611
PSA	70.67000
LogP	0.98
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.689
Storage condition	2-8°C
Water Solubility	slightly soluble

6,7-Dihydroxycoumarin MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GN6382500

CHEMICAL NAME :: Coumarin, 6,7-dihydroxy-

CAS REGISTRY NUMBER :: 305-01-1

BEILSTEIN REFERENCE NO. :: 0152788

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C9-H6-O4

MOLECULAR WEIGHT :: 178.15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 64,714,1968

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	GN6382500
Packaging Group	I; II; III
HS Code	2932209090

Precursor 9
CAS#:494-56-4 [1,3]dioxolo[4,... CAS#:617-48-1 (±)-Malic Acid CAS#:613-03-6 1,2,4-Triacetox... CAS#:92-61-5 Scopoletin
CAS#:331-39-5 Caffeic acid CAS#:108-24-7 Ethanoic anhydride CAS#:93-35-6 7-Hydroxycoumarine CAS#:106-51-4 1,4-Benzoquinone
CAS#:533-73-3 1,2,4-Trihydrox...
DownStream 10
CAS#:529-84-0 6,7-Dihydroxy-4... CAS#:92-61-5 Scopoletin CAS#:482-82-6 Nordalbergin CAS#:64-18-6 Formic Acid
CAS#:99-50-3 protocatechuic acid CAS#:144-62-7 Oxalic acid CAS#:13209-79-5 (-)-Prantschimgin CAS#:120-08-1 Scoparone
CAS#:15017-41-1 6,7-dihydroxy-3... CAS#:66301-01-7 6-hydroxy-7-pro...

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Coumarins as new matrices for matrix-assisted laser-desorption/ionization Fourier transform ion cyclotron resonance mass spectrometric analysis of hydrophobic compounds.

Anal. Chim. Acta 882 , 49-57, (2015)

Hydrophobic compounds with hydroxyl, aldehyde or ketone groups are generally difficult to detect using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS), because these compounds...

The influence of chronic eicosanoid biosynthesis inhibition on life history of the greater waxmoth, Galleria mellonella and its ectoparasitoid, Bracon hebetor.

J. Insect Physiol. 57(4) , 501-7, (2011)

Eicosanoids are oxygenated metabolites of three C20 polyunsaturated fatty acids, mainly arachidonic acid (AA; 20:4n-6), but also 20:3n-6 and 20:5n-3. Aside from their importance in biomedicine, eicosa...

Zinc oxide nanoparticles induce lipoxygenase-mediated apoptosis and necrosis in human neuroblastoma SH-SY5Y cells.

Neurochem. Int. 90 , 204-14, (2015)

Zinc oxide nanoparticles (ZnO NPs) are known to induce oxidative stress and modulate an inflammatory process in various cell types. Although the cytotoxic effects of ZnO NPs in various cell types have...

Aesculetin

Cryptotanshinone

ESCULETOL

CICHERINGENIN

Cichorigenin

Asculetine

Esculatin

6,7-Dihydroxycoumarin

Esculin aglycon

6,7-Dihydroxy-2H-chromen-2-one

esculetin

2H-1-Benzopyran-2-one, 6,7-dihydroxy-

6,7-dihydroxy-2H-1-benzopyran-2-one

Coumarin, 6,7-dihydroxy-

MFCD00006874

EINECS 206-161-5

BioBioPha
China
Product Name: 6,7-Dihydroxycoumarin
Price: ￥Inquiry/50mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 6,7-Dihydroxycoumarin
Price: ￥68.0/20mg ￥348.0/5g ￥118.0/1g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Esculetin
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Esculetin
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Esculetin
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: TIANFU-CHEM - Esculetin
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

Get all suppliers and price by the below link:

6,7-Dihydroxycoumarin suppliers

Price: ￥105.8/1g

Reference only. check more 6,7-Dihydroxycoumarin price

6,7-Dihydroxycoumarin

Use of 6,7-Dihydroxycoumarin

Names