AM-6761
Modify Date: 2024-04-09 15:21:16
AM-6761 structure
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Common Name | AM-6761 | ||
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| CAS Number | 1584732-36-4 | Molecular Weight | 695.692 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 821.7±65.0 °C at 760 mmHg | |
| Molecular Formula | C33H37Cl2FN2O5S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 450.8±34.3 °C | |
Use of AM-6761A potent MDM2-p53 interaction inhibitor with remarkable biochemical (HTRF IC50=0.1 nM), cellular potency (SJSA-1 EdU IC50=16 nM), and favorable pharmacokinetic properties; shows excellent antitumor activity in the SJSA-1 osteosarcoma xenograft model with ED50 of 11 mg/kg. |
| Name | (2-{[(3r,5r,6s)-1-[(1s)-2-(Tert-Butylsulfonyl)-1-Cyclopropylethyl]-6-(4-Chloro-3-Fluorophenyl)-5-(3-Chlorophenyl)-3-Methyl-2-Oxopiperidin-3-Yl]methyl}-1,3-Thiazol-5-Yl)acetic Acid |
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| Synonym | More Synonyms |
| Description | A potent MDM2-p53 interaction inhibitor with remarkable biochemical (HTRF IC50=0.1 nM), cellular potency (SJSA-1 EdU IC50=16 nM), and favorable pharmacokinetic properties; shows excellent antitumor activity in the SJSA-1 osteosarcoma xenograft model with ED50 of 11 mg/kg. |
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| References | References 1. Gonzalez AZ, et al. J Med Chem. 2014 Apr 10;57(7):2963-88. View Related Products by Target MDM2-p53 |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 821.7±65.0 °C at 760 mmHg |
| Molecular Formula | C33H37Cl2FN2O5S2 |
| Molecular Weight | 695.692 |
| Flash Point | 450.8±34.3 °C |
| Exact Mass | 694.150513 |
| LogP | 6.72 |
| Vapour Pressure | 0.0±3.1 mmHg at 25°C |
| Index of Refraction | 1.611 |
| (2-{[(3R,5R,6S)-6-(4-Chloro-3-fluorophenyl)-5-(3-chlorophenyl)-1-{(1S)-1-cyclopropyl-2-[(2-methyl-2-propanyl)sulfonyl]ethyl}-3-methyl-2-oxo-3-piperidinyl]methyl}-1,3-thiazol-5-yl)acetic acid |
| (2-{[(3r,5r,6s)-1-[(1s)-2-(Tert-Butylsulfonyl)-1-Cyclopropylethyl]-6-(4-Chloro-3-Fluorophenyl)-5-(3-Chlorophenyl)-3-Methyl-2-Oxopiperidin-3-Yl]methyl}-1,3-Thiazol-5-Yl)acetic Acid |
| 5-Thiazoleacetic acid, 2-[[(3R,5R,6S)-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-1-[(1S)-1-cyclopropyl-2-[(1,1-dimethylethyl)sulfonyl]ethyl]-3-methyl-2-oxo-3-piperidinyl]methyl]- |