TUG-499
Modify Date: 2024-09-08 17:18:40
TUG-499 structure
|
Common Name | TUG-499 | ||
|---|---|---|---|---|
| CAS Number | 1206629-08-4 | Molecular Weight | 320.17 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H11Cl2NO2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TUG-499TUG-499 is a selective free fatty acid receptor 1 (FFAR1 or GPR40) (Free Fatty Acid Receptor) agonist with a pEC50 of 7.39. TUG-499 exhibits >100-fold selectivity over the related receptors FFA2, FFA3, and the nuclear receptor PPARγ and other diverse receptors, ion channels, and transporters. TUG-499 can be used for the research of type 2 diabetes[1]. |
| Name | TUG-499 |
|---|
| Description | TUG-499 is a selective free fatty acid receptor 1 (FFAR1 or GPR40) (Free Fatty Acid Receptor) agonist with a pEC50 of 7.39. TUG-499 exhibits >100-fold selectivity over the related receptors FFA2, FFA3, and the nuclear receptor PPARγ and other diverse receptors, ion channels, and transporters. TUG-499 can be used for the research of type 2 diabetes[1]. |
|---|---|
| Related Catalog | |
| Target |
pEC50: 7.39 (FFAR1)[1] |
| In Vitro | TUG-499 (compound 7) demonstrates high chemical stability, no inhibition of selected CYP enzymes or P-glycoprotein, and excellent Caco-2 permeability. TUG-499 has potent activity on recombinant human FFA1 receptors and on the rat insulinoma cell line INS-1E[1]. |
| References |
| Molecular Formula | C16H11Cl2NO2 |
|---|---|
| Molecular Weight | 320.17 |