Antimalarial agent 11

Modify Date: 2025-09-01 17:25:51

Antimalarial agent 11 Structure
Antimalarial agent 11 structure
Common Name Antimalarial agent 11
CAS Number 1214454-56-4 Molecular Weight 425.47
Density N/A Boiling Point N/A
Molecular Formula C25H25F2NO3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Antimalarial agent 11


Antimalarial agent 11 (compound 1), a spirocyclic chromane, is a potent antimalarial agent. Antimalarial agent 11 exhibits excellent potency with an EC50 of 350 nM against the Chloroquine-resistant Dd2 strain. Antimalarial agent 11 has EC50s of 1.48 µM and 1.81 µM against D6 and ARC08-022 strains, respectively[1].

 Names

Name Antimalarial agent 11

 Antimalarial agent 11 Biological Activity

Description Antimalarial agent 11 (compound 1), a spirocyclic chromane, is a potent antimalarial agent. Antimalarial agent 11 exhibits excellent potency with an EC50 of 350 nM against the Chloroquine-resistant Dd2 strain. Antimalarial agent 11 has EC50s of 1.48 µM and 1.81 µM against D6 and ARC08-022 strains, respectively[1].
Related Catalog
References

[1]. Iredia D Iyamu, et al. Structure-activity and structure-property relationship studies of spirocyclic chromanes with antimalarial activity. Bioorg Med Chem. 2022 Mar 1;57:116629.

 Chemical & Physical Properties

Molecular Formula C25H25F2NO3
Molecular Weight 425.47
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