HuR inhibitor KH-3
Modify Date: 2024-01-06 18:27:22
HuR inhibitor KH-3 structure
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Common Name | HuR inhibitor KH-3 | ||
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| CAS Number | 1215115-03-9 | Molecular Weight | 430.537 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H22N2O4S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HuR inhibitor KH-3HuR inhibitor KH-3 is a small molecule, selective inhibitior of HuR function with Ki of 0.83 and 0.72 uM in FP and AlphaLISA assays, respectively.KH-3 potently inhibits breast cancer cell growth in vitro and in vivo.KH-3 inhibits breast cancer cell invasion in vitro as well as delays initiation of lung colonies and improves mouse survival in an experimental metastasis model in vivo.KH-3 suppresses breast cancer cell invasion by disrupting HuR-FOXQ1 mRNA interaction.Inhibition of HuR with KH-3 yielded a significant reduced in the progression of pathological cardiac hypertrophy in a transverse aortic constriction model. |
| Name | HuR inhibitor KH-3 |
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| Description | HuR inhibitor KH-3 is a small molecule, selective inhibitior of HuR function with Ki of 0.83 and 0.72 uM in FP and AlphaLISA assays, respectively.KH-3 potently inhibits breast cancer cell growth in vitro and in vivo.KH-3 inhibits breast cancer cell invasion in vitro as well as delays initiation of lung colonies and improves mouse survival in an experimental metastasis model in vivo.KH-3 suppresses breast cancer cell invasion by disrupting HuR-FOXQ1 mRNA interaction.Inhibition of HuR with KH-3 yielded a significant reduced in the progression of pathological cardiac hypertrophy in a transverse aortic constriction model. |
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| References | 1. Xiaoqing Wu, et al. Commun Biol. 2020 Apr 24;3(1):193. 2. Simeng Liu, et al. Clin Sci (Lond). 2020 Jun 26;134(12):1433-1448. |
| Molecular Formula | C21H22N2O4S2 |
|---|---|
| Molecular Weight | 430.537 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: HuR inhibitor KH-3
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: HuR inhibitor KH-3
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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