N-Desethyl amodiaquine-d5 dihydrochloride

Modify Date: 2024-01-20 19:31:40

N-Desethyl amodiaquine-d5 dihydrochloride structure	Common Name	N-Desethyl amodiaquine-d5 dihydrochloride
	CAS Number	1216894-33-5	Molecular Weight	405.76100
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₅Cl₃D₅N₃O	Melting Point	N/A
	MSDS	N/A	Flash Point	48.2 °F
	Symbol	GHS02, GHS06, GHS08	Signal Word	Danger

Use of N-Desethyl amodiaquine-d5 dihydrochloride

N-Desethyl amodiaquine-d5 dihydrochloride is the deuterium labeled N-Desethyl amodiaquine dihydrochloride. N-Desethyl amodiaquine dihydrochloride is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine dihydrochloride is an antiparasitic agent. IC50 values for strains V1/S and 3D7 are 97 nM and 25 nM, respectively[1].

Name	4-[(7-chloroquinolin-4-yl)amino]-2-[(1,1,2,2,2-pentadeuterioethylamino)methyl]phenol,dihydrochloride
Synonym	More Synonyms

Description	N-Desethyl amodiaquine-d5 dihydrochloride is the deuterium labeled N-Desethyl amodiaquine dihydrochloride. N-Desethyl amodiaquine dihydrochloride is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine dihydrochloride is an antiparasitic agent. IC50 values for strains V1/S and 3D7 are 97 nM and 25 nM, respectively[1].
Related Catalog	Research Areas >> Infection
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Sasi P, et al. In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa. J Infect Dis. 2009 Jun 1;199(11):1575-82.

Molecular Formula	C₁₈H₁₅Cl₃D₅N₃O
Molecular Weight	405.76100
Exact Mass	404.09900
PSA	57.18000
LogP	6.51480

MSDS(Chinese)

Symbol	GHS02, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H225-H301 + H311 + H331-H370
Precautionary Statements	P210-P260-P280-P301 + P310-P311
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
Flash Point(F)	48.2 °F
Flash Point(C)	9 °C

Phenol,4-[(7-chloro-4-quinolinyl)amino]-2-[(ethylamino)methyl]-,dihydrochloride (9CI)

[2H5]-Desethylamodiaquine hydrochloride

hloride (5CI)

N-Desethyl amodiaquine-d5 dihydrochloride

Use of N-Desethyl amodiaquine-d5 dihydrochloride

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