HA 130
Modify Date: 2024-01-03 18:39:49
HA 130 structure
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Common Name | HA 130 | ||
|---|---|---|---|---|
| CAS Number | 1229652-21-4 | Molecular Weight | 463.28600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H19BFNO5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HA 130HA130 is a selective ATX (autotaxin) inhibitor with IC50 of 28 nM. IC50 value: 28 nM [2]Target: ATXin vitro: HA130 completely blocks the ability of ATX to promote TEM (transendothelial migration). HA130 at 0.3 μM completely ablates the activity of ATX on TK1 uropod formation. [1]in vivo: HA130 instantaneously lowers plasma levels of LPA in mice after intravenous administration. HA130 is an inhibitor of the enzymatic activity of ATX, slows T cell migration across lymph node HEVs. HA130 decreased the "outside HEVs/inside HEVs" ratio by 3-4-fold, compared to vehicle-treated animals vehicle (p < 0.01 for both PLNs and MLNs). [1] |
| Name | [4-[[4-[(Z)-[3-[(4-fluorophenyl)methyl]-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl]phenoxy]methyl]phenyl]boronic acid |
|---|---|
| Synonym | More Synonyms |
| Description | HA130 is a selective ATX (autotaxin) inhibitor with IC50 of 28 nM. IC50 value: 28 nM [2]Target: ATXin vitro: HA130 completely blocks the ability of ATX to promote TEM (transendothelial migration). HA130 at 0.3 μM completely ablates the activity of ATX on TK1 uropod formation. [1]in vivo: HA130 instantaneously lowers plasma levels of LPA in mice after intravenous administration. HA130 is an inhibitor of the enzymatic activity of ATX, slows T cell migration across lymph node HEVs. HA130 decreased the "outside HEVs/inside HEVs" ratio by 3-4-fold, compared to vehicle-treated animals vehicle (p < 0.01 for both PLNs and MLNs). [1] |
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| Related Catalog | |
| References |
| Molecular Formula | C24H19BFNO5S |
|---|---|
| Molecular Weight | 463.28600 |
| Exact Mass | 463.10600 |
| PSA | 112.37000 |
| LogP | 3.25890 |
| Storage condition | 2-8℃ |
|
~64%
HA 130 CAS#:1229652-21-4 |
| Literature: Journal of Medicinal Chemistry, , vol. 53, # 13 p. 4958 - 4967 |
![3-[(4-fluorophenyl)methyl]-1,3-thiazolidine-2,4-dione structure](https://image.chemsrc.com/caspic/110/137660-67-4.png)
| Precursor 1 | |
|---|---|
| DownStream 0 | |
| MPP dihydrochloride |
| B-[3-[[4-[[3-[(4-Fluorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]phenyl]boronic Acid |
| 3-[(4-{[3-(4-fluorobenzyl)-2,4-dioxo-1,3-thiazolan-5-yliden]methyl}phenoxy)methyl]benzeneboronic acid |
| HA 150 |
| HA130 |