HA-100 hydrochloride

Modify Date: 2024-01-09 18:52:50

HA-100 hydrochloride structure	Common Name	HA-100 hydrochloride
	CAS Number	141543-63-7	Molecular Weight	313.80300
	Density	N/A	Boiling Point	497.4ºC at 760 mmHg
	Molecular Formula	C₁₃H₁₆ClN₃O₂S	Melting Point	252-254ºC
	MSDS	N/A	Flash Point	254.6ºC

Use of HA-100 hydrochloride

HA-100 hydrochloride is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 hydrochloride also used as a ROCK inhibitor[1][2].

Name	1-(5-Isoquinolinesulfonyl)piperazine Hydrochloride
Synonym	More Synonyms

Description	HA-100 hydrochloride is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 hydrochloride also used as a ROCK inhibitor[1][2].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Research Areas >> Cancer Signaling Pathways >> Cytoskeleton >> Myosin Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Signaling Pathways >> Stem Cell/Wnt >> PKA Signaling Pathways >> Cell Cycle/DNA Damage >> ROCK Signaling Pathways >> TGF-beta/Smad >> PKC Signaling Pathways >> Stem Cell/Wnt >> ROCK Signaling Pathways >> TGF-beta/Smad >> ROCK
Target	PKG:4 μM (IC50) PKA:8 μM (IC50) PKC:12 μM (IC50) MLCK:240 μM (IC50) ROCK
In Vitro	HA-100 hydrochloride inhibits MLC-kinase and PKC competitively with respect to ATP, with Kis of 61 and 6.5 μM, respectively[1].
References	[1]. Hagiwara M, et, al. Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives. Mol Pharmacol. 1987 Jul;32(1):7-12. [2]. Yu J, et, al. Efficient feeder-free episomal reprogramming with small molecules. PLoS One. 2011 Mar 1;6(3):e17557.

Boiling Point	497.4ºC at 760 mmHg
Melting Point	252-254ºC
Molecular Formula	C₁₃H₁₆ClN₃O₂S
Molecular Weight	313.80300
Flash Point	254.6ºC
Exact Mass	313.06500
PSA	70.68000
LogP	2.97820