HA-100 hydrochloride

Modify Date: 2024-01-09 18:52:50

HA-100 hydrochloride structure	Common Name	HA-100 hydrochloride
	CAS Number	141543-63-7	Molecular Weight	313.80300
	Density	N/A	Boiling Point	497.4ºC at 760 mmHg
	Molecular Formula	C₁₃H₁₆ClN₃O₂S	Melting Point	252-254ºC
	MSDS	N/A	Flash Point	254.6ºC

Use of HA-100 hydrochloride

HA-100 hydrochloride is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 hydrochloride also used as a ROCK inhibitor[1][2].

Name	1-(5-Isoquinolinesulfonyl)piperazine Hydrochloride
Synonym	More Synonyms

Description	HA-100 hydrochloride is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 hydrochloride also used as a ROCK inhibitor[1][2].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Research Areas >> Cancer Signaling Pathways >> Cytoskeleton >> Myosin Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Signaling Pathways >> Stem Cell/Wnt >> PKA Signaling Pathways >> Cell Cycle/DNA Damage >> ROCK Signaling Pathways >> TGF-beta/Smad >> PKC Signaling Pathways >> Stem Cell/Wnt >> ROCK Signaling Pathways >> TGF-beta/Smad >> ROCK
Target	PKG:4 μM (IC50) PKA:8 μM (IC50) PKC:12 μM (IC50) MLCK:240 μM (IC50) ROCK
In Vitro	HA-100 hydrochloride inhibits MLC-kinase and PKC competitively with respect to ATP, with Kis of 61 and 6.5 μM, respectively[1].
References	[1]. Hagiwara M, et, al. Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives. Mol Pharmacol. 1987 Jul;32(1):7-12. [2]. Yu J, et, al. Efficient feeder-free episomal reprogramming with small molecules. PLoS One. 2011 Mar 1;6(3):e17557.

Boiling Point	497.4ºC at 760 mmHg
Melting Point	252-254ºC
Molecular Formula	C₁₃H₁₆ClN₃O₂S
Molecular Weight	313.80300
Flash Point	254.6ºC
Exact Mass	313.06500
PSA	70.68000
LogP	2.97820

Hazard Codes	Xi

Piperazine

CAS#:110-85-0

ISOQUINOLINE-5-...

CAS#:84468-15-5

HA-100 hydrochloride

CAS#:141543-63-7

Literature: Morikawa; Sone; Asano Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 3 p. 770 - 773

Precursor 2
CAS#:110-85-0 Piperazine CAS#:84468-15-5 ISOQUINOLINE-5-...
DownStream 0

5-piperazin-1-ylsulfonylisoquinoline,hydrochloride

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-(5-ISOQUINOLINESULFONYL)PIPERAZINEHYDROCHLORIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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