Diethyl succinate

Modify Date: 2024-01-02 08:54:11

Diethyl succinate Structure
Diethyl succinate structure
Common Name Diethyl succinate
CAS Number 123-25-1 Molecular Weight 174.194
Density 1.0±0.1 g/cm3 Boiling Point 218.4±8.0 °C at 760 mmHg
Molecular Formula C8H14O4 Melting Point -20 °C
MSDS Chinese USA Flash Point 90.6±0.0 °C

 Use of Diethyl succinate


Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring[1].

 Names

Name Diethyl succinate
Synonym More Synonyms

 Diethyl succinate Biological Activity

Description Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring[1].
Related Catalog
References

[1]. Zacharias NM, et al. Real-time molecular imaging of tricarboxylic acid cycle metabolism in vivo by hyperpolarized 1-(13)C diethyl succinate. J Am Chem Soc. 2012 Jan 18;134(2):934-43.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 218.4±8.0 °C at 760 mmHg
Melting Point -20 °C
Molecular Formula C8H14O4
Molecular Weight 174.194
Flash Point 90.6±0.0 °C
Exact Mass 174.089203
PSA 52.60000
LogP 1.26
Vapour density 6 (vs air)
Vapour Pressure 0.1±0.4 mmHg at 25°C
Index of Refraction 1.423

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WM7400000
CHEMICAL NAME :
Succinic acid, diethyl ester
CAS REGISTRY NUMBER :
123-25-1
BEILSTEIN REFERENCE NO. :
0907645
LAST UPDATED :
199806
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C8-H14-O4
MOLECULAR WEIGHT :
174.22
WISWESSER LINE NOTATION :
2OV2VO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 16,707,1978
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rat
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 16,707,1978
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,374,1986 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8530 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 4,119,1951 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3671 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 82 (estimated) No. of Female Employees: 14 (estimated)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26-S36-S24/25-S22
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS WM7400000
HS Code 29171990

 Synthetic Route

 Customs

HS Code 29171990

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 Synonyms

succinic acid diethyl ester
Butanedioic acid diethyl ester
EINECS 204-612-0
MFCD00009208
Butamedioic acid diethyl ester
Diethyl Butanedioate
Butanedioic acid, diethyl ester
diethyl butane-1,4-dioate
Diethyl succinate
Ethyl Succinate
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