HG-7-85-01-NH2

Modify Date: 2025-08-27 10:15:52

HG-7-85-01-NH2 Structure
HG-7-85-01-NH2 structure
Common Name HG-7-85-01-NH2
CAS Number 1258391-29-5 Molecular Weight 540.60
Density N/A Boiling Point N/A
Molecular Formula C27H27F3N6OS Melting Point N/A
MSDS N/A Flash Point N/A

 Use of HG-7-85-01-NH2


HG-7-85-01-NH2 is the ligand of SNIPER(ABL)-033. SNIPER(ABL)-033, conjugating HG-7-85-01 (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 value of 0.3 μM[1].

 Names

Name HG-7-85-01-NH2

 HG-7-85-01-NH2 Biological Activity

Description HG-7-85-01-NH2 is the ligand of SNIPER(ABL)-033. SNIPER(ABL)-033, conjugating HG-7-85-01 (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 value of 0.3 μM[1].
Related Catalog
References

[1]. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.

 Chemical & Physical Properties

Molecular Formula C27H27F3N6OS
Molecular Weight 540.60
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