Sulfolane

Modify Date: 2025-08-20 12:05:56

Sulfolane structure	Common Name	Sulfolane
	CAS Number	126-33-0	Molecular Weight	120.170
	Density	1.3±0.1 g/cm3	Boiling Point	285.6±8.0 °C at 760 mmHg
	Molecular Formula	C₄H₈O₂S	Melting Point	27.4 °C
	MSDS	Chinese USA	Flash Point	165.6±0.0 °C
	Symbol	GHS07	Signal Word	Warning

Name	sulfolane
Synonym	More Synonyms

Density	1.3±0.1 g/cm3
Boiling Point	285.6±8.0 °C at 760 mmHg
Melting Point	27.4 °C
Molecular Formula	C₄H₈O₂S
Molecular Weight	120.170
Flash Point	165.6±0.0 °C
Exact Mass	120.024498
PSA	42.52000
LogP	-0.77
Vapour density	4.2 (vs air)
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.486
InChIKey	HXJUTPCZVOIRIF-UHFFFAOYSA-N
SMILES	O=S1(=O)CCCC1
Stability	Stable. Combustible. Incompatible with strong oxidizing agents.
Water Solubility	soluble
Freezing Point	26℃

Sulfolane MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XN0700000

CHEMICAL NAME :: Thiophene, tetrahydro-, 1,1-dioxide

CAS REGISTRY NUMBER :: 126-33-0

BEILSTEIN REFERENCE NO. :: 0107765

LAST UPDATED :: 199712

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C4-H8-O2-S

MOLECULAR WEIGHT :: 120.18

WISWESSER LINE NOTATION :: T5SWTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944- Volume(issue)/page/year: 23,302,1966 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1540 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >250 mg/m3/8H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0535072

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >3800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944- Volume(issue)/page/year: 23,302,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 4,22,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1620 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0535072

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,560,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1250 mg/kg

TOXIC EFFECTS :: Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation

REFERENCE :: RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 42,97,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1080 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 119,423,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3180 uL/kg

TOXIC EFFECTS :: Liver - other changes Kidney, Ureter, Bladder - other changes Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0535072 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6750 mg/kg/2W-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533719

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 6350 mg/kg/23W-I

TOXIC EFFECTS :: Vascular - pulse pressure increase

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533719

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 495 mg/m3/8H/27D-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Liver - fatty liver degeneration Related to Chronic Data - death

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 40,463,1977

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 200 mg/m3/23H/90D-C

TOXIC EFFECTS :: Blood - changes in leukocyte (WBC) count

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 40,463,1977 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80612 No. of Facilities: 27 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 143 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80612 No. of Facilities: 386 (estimated) No. of Industries: 5 No. of Occupations: 10 No. of Employees: 6635 (estimated) No. of Female Employees: 322 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22
Safety Phrases	S23-S25
RIDADR	NONH for all modes of transport
WGK Germany	1
RTECS	XN0700000
HS Code	29349990

Thiophane

CAS#:110-01-0

~99%

Sulfolane

CAS#:126-33-0

Literature: Synthetic Communications, , vol. 28, # 16 p. 2983 - 2998

Tetrahydrothiop...

CAS#:1600-44-8

~66%

Sulfolane

CAS#:126-33-0

Literature: Journal of Organic Chemistry, , vol. 48, # 20 p. 3585 - 3587

Thiophane

CAS#:110-01-0

~9%

Tetrahydrothiop...

CAS#:1600-44-8

Sulfolane

CAS#:126-33-0

Literature: Organic Letters, , vol. 1, # 2 p. 189 - 191

1,4-Dibromobutane

CAS#:110-52-1

~44%

Sulfolane

CAS#:126-33-0

1,2-Oxathiane, ...

CAS#:24308-29-0

Literature: Monatshefte fuer Chemie, , vol. 113, p. 37 - 42

1-methyl-4-[4-(...

CAS#:4724-56-5

~45%

Sulfolane

CAS#:126-33-0

1,2-Oxathiane, ...

CAS#:24308-29-0

Literature: Monatshefte fuer Chemie, , vol. 113, p. 37 - 42

Thiophene,tetra...

CAS#:17200-23-6

Sulfolane

CAS#:126-33-0

Literature: US2435404 , ;

Thiophane

CAS#:110-01-0

Tetrahydrothiop...

CAS#:1600-44-8

Sulfolane

CAS#:126-33-0

4-butanal disulfide

CAS#:102244-56-4

Literature: Journal of Organic Chemistry, , vol. 67, # 26 p. 9368 - 9378

Thiophene,2,3-d...

CAS#:1192-16-1

Sulfolane

CAS#:126-33-0

Literature: J. Appl. Chem. USSR (Engl. Transl.), , vol. 63, # 6.2. p. 1348 - 1350,1233 - 1235

Precursor 6
CAS#:110-01-0 Thiophane CAS#:1600-44-8 Tetrahydrothiop... CAS#:110-52-1 1,4-Dibromobutane CAS#:4724-56-5 1-methyl-4-[4-(...
CAS#:17200-23-6 Thiophene,tetra... CAS#:1192-16-1 Thiophene,2,3-d...
DownStream 10
CAS#:350-46-9 1-Fluoro-4-nitr... CAS#:350-30-1 3-Chloro-4-fluo... CAS#:375-72-4 Perfluorobutane... CAS#:446-35-5 2,4-Difluoronit...
CAS#:393-01-1 2,3,4-trifluoro... CAS#:120770-03-8 2-CHLORO-1,3-DI... CAS#:21792-52-9 Benzene,1,2-die... CAS#:29866-60-2 2-Thiophenemeth...
CAS#:880-78-4 perfluoronitrob... CAS#:626-17-5 Isophthalonitrile

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Remarkably regioselective deacylation of cellulose esters using tetraalkylammonium salts of the strongly basic hydroxide ion.

Carbohydr. Polym. 111 , 25-32, (2014)

Tetraalkylammonium hydroxides have been found to mediate regioselective deacylation of cellulose esters. This deacylation surprisingly shows substantial selectivity for the removal of the acyl groups ...

Impurity profiling of ibandronate sodium by HPLC-CAD.

J. Pharm. Biomed. Anal. 114 , 254-64, (2015)

The modern bisphosphonate drug ibandronate sodium, a challenging candidate for impurity profiling, was analyzed using high performance liquid chromatography (HPLC) combined with corona charged aerosol...

Interaction of High Flash Point Electrolytes and PE-Based Separators for Li-Ion Batteries.

Int. J. Mol. Sci. 16 , 20258-76, (2015)

In this study, promising electrolytes for use in Li-ion batteries are studied in terms of interacting and wetting polyethylene (PE) and particle-coated PE separators. The electrolytes are characterize...

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: qHTS assay to identify small molecule antagonists of the peroxisome proliferator-acti...
Source: 824
Target: N/A
External Id: PPARGV841

Name: qHTS assay to identify small molecule agonists of the TGF-beta/Smad signaling pathway...
Source: 824
Target: N/A
External Id: TGF788

Name: qHTS assay to identify small molecule antagonists of the TGF-beta/Smad signaling path...
Source: 824
Target: N/A
External Id: TGF602

Name: qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cell fr...
Source: 824
Target: N/A
External Id: SPEC167MG

Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600

Name: qHTS assay to identify small molecule agonists of the peroxisome proliferator-activat...
Source: 824
Target: N/A
External Id: PPARDV813

Name: qHTS assay to test for compound auto fluorescence at 590 nm (red) in HEK293 cell free...
Source: 824
Target: N/A
External Id: SPEC167MR

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958

Name: qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cells
Source: 824
Target: N/A
External Id: SPEC167CG

Total 186, Current Page 1 of 19

Thiocyclopentane-1,1-dioxide

bondelanea

tetramethylene sulfone

SULFOLAN

Thiolane-1,1-dioxide

Sulfolane

Thiophene, tetrahydro-, 1,1-dioxide

Tetrahydrothiophene 1,1-dioxide

Tetrahydrothiophene, 1,1-dioxide

Sulfalone

Bondolane A

2,3,4,5-Tetrahydrothiophene-1,1-dioxide

1,1-dioxothiolan

5-17-01-00039 (Beilstein Handbook Reference)

MFCD00005484

EINECS 204-783-1

tetrahydro-thiophene-1,1-dioxide

SULPHOLANE

tetrahydrothiophene dioxide

Sulfolone

Supholane

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Delivery: Inquiry
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Sulfolane

Names

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Synthetic Route

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Articles29

SulfolaneBioassay

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