m-PEG4-amino-Mal

Modify Date: 2024-01-02 10:08:23

m-PEG4-amino-Mal Structure
m-PEG4-amino-Mal structure
Common Name m-PEG4-amino-Mal
CAS Number 1263044-81-0 Molecular Weight 358.387
Density 1.2±0.1 g/cm3 Boiling Point 548.7±50.0 °C at 760 mmHg
Molecular Formula C16H26N2O7 Melting Point N/A
MSDS N/A Flash Point 285.6±30.1 °C

 Use of m-PEG4-amino-Mal


m-PEG4-amino-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(2,5,8,11-tetraoxatridecan-13-yl)propanamide
Synonym More Synonyms

 m-PEG4-amino-Mal Biological Activity

Description m-PEG4-amino-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 548.7±50.0 °C at 760 mmHg
Molecular Formula C16H26N2O7
Molecular Weight 358.387
Flash Point 285.6±30.1 °C
Exact Mass 358.174011
LogP -2.06
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.499

 Synonyms

1H-Pyrrole-1-propanamide, 2,5-dihydro-2,5-dioxo-N-3,6,9,12-tetraoxatridec-1-yl-
3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(2,5,8,11-tetraoxatridecan-13-yl)propanamide
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