Peptide YY Fragment 3-36 human

Modify Date: 2024-01-05 18:18:36

Peptide YY Fragment 3-36 human structure	Common Name	Peptide YY Fragment 3-36 human
	CAS Number	126339-09-1	Molecular Weight	3980.42
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇₆H₂₇₂N₅₂O₅₄	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of Peptide YY Fragment 3-36 human

Peptide YY (PYY) (3-36), human is a gut hormone peptide that acts as a Y2 receptor agonist to reduce appetite.

Name	Peptide YY (PYY) (3-36), human
Synonym	More Synonyms

Description	Peptide YY (PYY) (3-36), human is a gut hormone peptide that acts as a Y2 receptor agonist to reduce appetite.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease Peptides
Target	Y2 receptor[1]
In Vitro	Peptide YY (PYY) (3-36), human is a Y2 receptor agonist, generated via cleaving the first two amino acids at the N terminus of PYY1-36 by enzyme dipeptidyl peptidase-IV (DPP-IV), and can reduces food intake[1].
In Vivo	In mice, actinonin significantly prolongs the anorectic effect of PYY3-36 (50 nmol/kg) and maintains higher PYY3-36 plasma levels than treatment with PYY3-36 alone[1].
Animal Admin	Mice[1] Mice are divided into four treatment groups and administered an injection (maximum volume, 100 μL, sc) of either: 1) saline (n = 10), 2) phosphoramidon (10 mg/kg) (n = 10), 3) PYY3-36 (50 nmol/kg) (n = 10), or 4) PYY3-36 (50 nmol/kg) and phosphoramidon (10 mg/kg) (n = 10). This dose of phosphoramidon inhibits NEP activity for 4 h. Body weight is measured at 0 and 24 h after injection. Food intake is measured at 1, 2, 3, 4, 8, and 24 h after injection[1].
References	[1]. Addison ML, et al. A role for metalloendopeptidases in the breakdown of the gut hormone, PYY 3-36. Endocrinology. 2011 Dec;152(12):4630-40.

Molecular Formula	C₁₇₆H₂₇₂N₅₂O₅₄
Molecular Weight	3980.42
Appearance of Characters	lyophilized powder
Storage condition	−20°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3

Characterization of neuropeptide Y (NPY) receptors in human cerebral arteries with selective agonists and the new Y1 antagonist BIBP 3226.

Br. J. Pharmacol. 116 , 2245-2250, (1995)

1. We have characterized pharmacologically the receptor subtype(s) responsible for the neuropeptide Y (NPY)-induced vasoconstriction in human cerebral arteries. NPY, PYY and several of their derivativ...

Peptide YY and neuropeptide Y: two peptides intimately involved in electrolyte homeostasis.

Trends Pharmacol. Sci. 17 , 436-438, (1996)

Reversal by NPY, PYY and 3-36 molecular forms of NPY and PYY of intracisternal CRF-induced inhibition of gastric acid secretion in rats.

Br. J. Pharmacol. 118 , 237-242, (1996)

1. The Y receptor subtype involved in the antagonism by neuropeptide Y (NPY) of intracisternal corticotropin-releasing factor (CRF)-induced inhibition of gastric acid secretion was studied in urethane...

MFCD00165623