Taraxerol
Taraxerol structure
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Common Name | Taraxerol | ||
|---|---|---|---|---|
| CAS Number | 127-22-0 | Molecular Weight | 426.717 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 490.7±44.0 °C at 760 mmHg | |
| Molecular Formula | C30H50O | Melting Point | 282-285° | |
| MSDS | USA | Flash Point | 217.7±20.7 °C | |
Use of TaraxerolTaraxerol is isolated from Abroma augusta L, and has anti-inflammtory and anti-cancer effects. Taraxerol attenuates acute inlammation through inhibition of NF-κB signaling pathway. Taraxerol induces cell apoptosis[1][2]. |
Summary: Taraxerol, Chinese name: 蒲公英赛醇, CAS number: 127-22-0, molecular formula: C30H50O, molecular weight: 426.717. Appears as a powder, melting point: 282-285°C, boiling point: 490.7±44.0 °C. For research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | taraxerol |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Taraxerol is isolated from Abroma augusta L, and has anti-inflammtory and anti-cancer effects. Taraxerol attenuates acute inlammation through inhibition of NF-κB signaling pathway. Taraxerol induces cell apoptosis[1][2]. |
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| Related Catalog | |
| Target |
IC50: apoptosis[1] |
| In Vitro | Taraxerol (0-100 μM; 24 or 48 hours)significantly reduces cell viability to 95% (20 μM), 89.8% (40 μM), 82.6 % (60 μM), 72.9 % (80 μM), and 63.6% (100 μM).And this compound has cell viability of 90.7% at a concentration of 20 μM and 53.6% at the 100 μM concentration at 48 hours in Hela cells[1]. Taraxerol (80 μM; 24 or 48 hours) induces Hela cells apoptosis and cell death in a dose-dependent manner.Taraxerol can induce a significant apoptosis of cells by annexin V/ PI double staining, significant increase in both the early (24.2%) and late (16.2%) stages of apoptotic cells compared with the control group at the early (6.5%) and late (0.5%) stages[1]. |
| In Vivo | Taraxerol (5 and 10mg/kg; i.p.) attenuates carrageenan induced paw edema 2h onward. The effect of taraxerol at the dose of 5mg/kg is found to be significant (p<0.05) only after 4h of carrageenan treatment[2]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 490.7±44.0 °C at 760 mmHg |
| Melting Point | 282-285° |
| Molecular Formula | C30H50O |
| Molecular Weight | 426.717 |
| Flash Point | 217.7±20.7 °C |
| Exact Mass | 426.386169 |
| PSA | 20.23000 |
| LogP | 11.06 |
| Vapour Pressure | 0.0±2.8 mmHg at 25°C |
| Index of Refraction | 1.539 |
| InChIKey | GGGUGZHBAOMSFJ-GADYQYKKSA-N |
| SMILES | CC1(C)CCC2(C)CC=C3C(C)(CCC4C3(C)CCC3C(C)(C)C(O)CCC43C)C2C1 |
| Storage condition | 2-8℃ |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Hazard Codes | Xi |
|---|---|
| RIDADR | NONH for all modes of transport |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 0 | |
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| DownStream 5 | |
CAS#:582-16-1
CAS#:488-23-3
CAS#:2131-43-3
CAS#:486-34-0
CAS#:1679-02-3This table lists relevant public references with title, journal and publication metadata for this compound.
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A new taraxerol derivative from the roots of Microcos tomentosa.
Nat. Prod. Commun. 8(10) , 1371-2, (2013) A new 3beta-O-vanilloyl-taraxerol, microcisin (1) and eight known compounds, 3beta-taraxerol acetate (2), 3beta-taraxerol (3), cholest-4-en-3-one (4), cholest-4-en-6beta-ol-3-one (5), beta-sitosterol ... |
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[Chemical constituents in the leave of Rhizophora stylosa L and their biological activities].
Yao Xue Xue Bao 43(9) , 974-8, (2008) Ten compounds were isolated from the leaves of Rhizophora stylosa, one kind of mangrove plants distributed in the tropical and subtropical areas of the world. Their structures were identified as tarax... |
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Taraxerol inhibits LPS-induced inflammatory responses through suppression of TAK1 and Akt activation.
Int. Immunopharmacol. 15(2) , 316-24, (2013) Taraxerol, a triterpenoid compound, has potent anti-inflammatory effects. However, the molecular mechanisms are not clear. In the study, taraxerol concentration dependently inhibited nitric-oxide synt... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| UNII-A32778O852 |
| D-Friedoolean-14-en-3beta-ol |
| Isoolean-14-en-3b-ol |
| alnulin |
| (3S,4aR,6aR,8aR,12aR,12bS,14aR,14bR)-4,4,6a,8a,11,11,12b,14b-Octamethyl-1,2,3,4,4a,5,6,6a,8,8a,9,10,11,12,12a,12b,13,14,14a,14b-icosahydro-3-picenol |
| Skimmiol |
| D-friedoolean-14-en-3β-ol |
| Taraxerol |
| Tiliadin |
| (3S,4aR,6aR,6aS,8aR,12aR,14aR,14bR)-4,4,6a,6a,8a,11,11,14b-octamethyl-1,2,3,4a,5,6,8,9,10,12,12a,13,14,14a-tetradecahydropicen-3-ol |
| D-Friedoolean-14-en-3b-ol |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the English name of taraxerol? |
| A: The English name of taraxerol is taraxerol. |
| Q: What are the uses of taraxerol? |
| A: Main uses of taraxerol: Taraxerol is isolated from Abroma augusta L, and has anti-inflammtory and anti-cancer effects. Taraxerol attenuates acute inlammation through inhibition of NF-κB signaling pathway. Taraxerol induces cell apoptosis[1][2]. |
| Q: What are the downstream products of taraxerol? |
| A: Related downstream products(CAS) of taraxerol: 582-16-1;488-23-3;2131-43-3;486-34-0;1679-02-3. |
| Q: What English synonyms does taraxerol have? |
| A: English synonyms of taraxerol: UNII-A32778O852, D-Friedoolean-14-en-3beta-ol, Isoolean-14-en-3b-ol, alnulin, (3S,4aR,6aR,8aR,12aR,12bS,14aR,14bR)-4,4,6a,8a,11,11,12b,14b-Octamethyl-1,2,3,4,4a,5,6,6a,8,8a,9,10,11,12,12a,12b,13,14,14a,14b-icosahydro-3-picenol, Skimmiol, D-friedoolean-14-en-3β-ol, Taraxerol, Tiliadin, (3S,4aR,6aR,6aS,8aR,12aR,14aR,14bR)-4,4,6a,6a,8a,11,11,14b-octamethyl-1,2,3,4a,5,6,8,9,10,12,12a,13,14,14a-tetradecahydropicen-3-ol, D-Friedoolean-14-en-3b-ol. |
| Q: What are the storage conditions for taraxerol? |
| A: Storage conditions for taraxerol: 2-8℃. |
| Q: What is the SMILES notation of taraxerol? |
| A: SMILES notation of taraxerol is CC1(C)CCC2(C)CC=C3C(C)(CCC4C3(C)CCC3C(C)(C)C(O)CCC43C)C2C1. |
| Q: What is the molecular formula of taraxerol? |
| A: Molecular formula of taraxerol is C30H50O. |
| Q: What is the InChIKey of taraxerol? |
| A: InChIKey of taraxerol is GGGUGZHBAOMSFJ-GADYQYKKSA-N. |
| Q: What is the molecular weight of taraxerol? |
| A: Molecular weight of taraxerol is 426.717. |
| Q: What is the CAS number of taraxerol? |
| A: CAS number of taraxerol is 127-22-0. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| naturewill |