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127-22-0

127-22-0 structure
127-22-0 structure
  • Name: Taraxerol
  • Chemical Name: taraxerol
  • CAS Number: 127-22-0
  • Molecular Formula: C30H50O
  • Molecular Weight: 426.717
  • Catalog: Natural product Moss
  • Create Date: 2018-10-17 18:20:58
  • Modify Date: 2024-01-02 19:06:38
  • Taraxerol is isolated from Abroma augusta L, and has anti-inflammtory and anti-cancer effects. Taraxerol attenuates acute inlammation through inhibition of NF-κB signaling pathway. Taraxerol induces cell apoptosis[1][2].
Name taraxerol
Synonyms UNII-A32778O852
D-Friedoolean-14-en-3beta-ol
Isoolean-14-en-3b-ol
alnulin
(3S,4aR,6aR,8aR,12aR,12bS,14aR,14bR)-4,4,6a,8a,11,11,12b,14b-Octamethyl-1,2,3,4,4a,5,6,6a,8,8a,9,10,11,12,12a,12b,13,14,14a,14b-icosahydro-3-picenol
3-Picenol, 1,2,3,4,4a,5,6,6a,8,8a,9,10,11,12,12a,12b,13,14,14a,14b-eicosahydro-4,4,6a,8a,11,11,12b,14b-octamethyl-, (3S,4aR,6aR,8aR,12aR,12bS,14aR,14bR)-
Skimmiol
D-friedoolean-14-en-3β-ol
Taraxerol
Tiliadin
(3S,4aR,6aR,6aS,8aR,12aR,14aR,14bR)-4,4,6a,6a,8a,11,11,14b-octamethyl-1,2,3,4a,5,6,8,9,10,12,12a,13,14,14a-tetradecahydropicen-3-ol
D-Friedoolean-14-en-3b-ol
Description Taraxerol is isolated from Abroma augusta L, and has anti-inflammtory and anti-cancer effects. Taraxerol attenuates acute inlammation through inhibition of NF-κB signaling pathway. Taraxerol induces cell apoptosis[1][2].
Related Catalog
Target

IC50: apoptosis[1]

In Vitro Taraxerol (0-100 μM; 24 or 48 hours)significantly reduces cell viability to 95% (20 μM), 89.8% (40 μM), 82.6 % (60 μM), 72.9 % (80 μM), and 63.6% (100 μM).And this compound has cell viability of 90.7% at a concentration of 20 μM and 53.6% at the 100 μM concentration at 48 hours in Hela cells[1]. Taraxerol (80 μM; 24 or 48 hours) induces Hela cells apoptosis and cell death in a dose-dependent manner.Taraxerol can induce a significant apoptosis of cells by annexin V/ PI double staining, significant increase in both the early (24.2%) and late (16.2%) stages of apoptotic cells compared with the control group at the early (6.5%) and late (0.5%) stages[1].
In Vivo Taraxerol (5 and 10mg/kg; i.p.) attenuates carrageenan induced paw edema 2h onward. The effect of taraxerol at the dose of 5mg/kg is found to be significant (p<0.05) only after 4h of carrageenan treatment[2].
References

[1]. Yaoi X, et al. Taraxerol Induces Cell Apoptosis through A Mitochondria-Mediated Pathway in HeLa Cells.Cell J. 2017 Oct;19(3):512-519.
Density 1.0±0.1 g/cm3
Boiling Point 490.7±44.0 °C at 760 mmHg
Melting Point 282-285°
Molecular Formula C30H50O
Molecular Weight 426.717
Flash Point 217.7±20.7 °C
Exact Mass 426.386169
PSA 20.23000
LogP 11.06
Vapour Pressure 0.0±2.8 mmHg at 25°C
Index of Refraction 1.539
Storage condition 2-8℃
Hazard Codes Xi
RIDADR NONH for all modes of transport

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title: CAS No. 127-22-0 | Chemsrc address: https://m.chemsrc.com/en/baike/44764.html

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