Ganglioside GM2

Modify Date: 2025-11-26 14:49:21

Use of Ganglioside GM2

Ganglioside GM2 is a human tumor antigen (OFA-I-1). Ganglioside GM2 is the major lysosomal storage compound of Tay-Sachs disease[1][2].

Name	Ganglioside GM2

Description	Ganglioside GM2 is a human tumor antigen (OFA-I-1). Ganglioside GM2 is the major lysosomal storage compound of Tay-Sachs disease[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Tai T, et al. Ganglioside GM2 as a human tumor antigen (OFA-I-1). Proc Natl Acad Sci U S A. 1983 Sep;80(17):5392-6. [2]. Anheuser S, et al. Membrane lipids regulate ganglioside GM2 catabolism and GM2 activator protein activity. J Lipid Res. 2015 Sep;56(9):1747-61. [3]. Nakamura K, et al. Dissection and optimization of immune effector functions of humanized anti-ganglioside GM2 monoclonal antibody. Mol Immunol. 2000 Dec;37(17):1035-46.

Description

Ganglioside GM2 is a human tumor antigen (OFA-I-1). Ganglioside GM2 is the major lysosomal storage compound of Tay-Sachs disease[1][2].

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

References

Molecular Formula	C₆₇H₁₂₁N₃O₂₆
Molecular Weight	1384.68
InChIKey	GIVLTTJNORAZON-HDBOBKCLSA-N
SMILES	CCCCCCCCCCCCCC=CC(O)C(COC1OC(CO)C(OC2OC(CO)C(OC3OC(CO)C(O)C(O)C3NC(C)=O)C(OC3(C(=O)O)CC(O)C(NC(C)=O)C(C(O)C(O)CO)O3)C2O)C(O)C1O)NC(=O)CCCCCCCCCCCCCCCCC