Fenoterol-d6 hydrobromide

Modify Date: 2024-01-02 18:52:46

Fenoterol-d6 hydrobromide Structure
Fenoterol-d6 hydrobromide structure
Common Name Fenoterol-d6 hydrobromide
CAS Number 1286129-04-1 Molecular Weight 390.30200
Density N/A Boiling Point N/A
Molecular Formula C17H16BrD6NO4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Fenoterol-d6 hydrobromide


Fenoterol-d6 hydrobromide (Th-1165a-d6) is the deuterium labeled Fenoterol hydrobromide. Fenoterol hydrobromide (Th-1165a), a sympathomimetic agent, is a selective and orally active β2-adrenoceptor agonist. Fenoterol hydrobromide is an effective bronchodilator and can be used for bronchospasm associated with asthma, bronchitis and other obstructive airway diseases research[1][2].

 Names

Name 5-[2-[[1,1,1,2,3,3-hexadeuterio-3-(4-hydroxyphenyl)propan-2-yl]amino]-1-hydroxyethyl]benzene-1,3-diol,hydrobromide
Synonym More Synonyms

 Fenoterol-d6 hydrobromide Biological Activity

Description Fenoterol-d6 hydrobromide (Th-1165a-d6) is the deuterium labeled Fenoterol hydrobromide. Fenoterol hydrobromide (Th-1165a), a sympathomimetic agent, is a selective and orally active β2-adrenoceptor agonist. Fenoterol hydrobromide is an effective bronchodilator and can be used for bronchospasm associated with asthma, bronchitis and other obstructive airway diseases research[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. R C Heel, et al. Fenoterol: a review of its pharmacological properties and therapeutic efficacy in asthma. Drugs. 1978 Jan;15(1):3-32.

[3]. Wei Wang, et al. Anti-inflammatory activities of fenoterol through β-arrestin-2 and inhibition of AMPK and NF-κB activation in AICAR-induced THP-1 cells. Biomed Pharmacother. 2016 Dec;84:185-190.

[4]. Nada Choucair-Jaafar, et al. Beta2-adrenoceptor agonists alleviate neuropathic allodynia in mice after chronic treatment. Br J Pharmacol. 2009 Dec;158(7):1683-94.

[5]. Amrita Datta, et al. High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer. Sci Rep. 2018 May 25;8(1):8161.

 Chemical & Physical Properties

Molecular Formula C17H16BrD6NO4
Molecular Weight 390.30200
Exact Mass 389.11100
PSA 92.95000
LogP 3.40660

 Synonyms

Fenoterol-d6 Hydrobromide
Airum-d6
Partusisten-d6
Berotec-d6
Phenoterol-d6 Hydrobromide
Fenoterol-d6 Bromide
Dosberotec-d6
Th 1165a-d6
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