Levocetirizine dihydrochloride
Modify Date: 2024-01-02 15:31:02
Levocetirizine dihydrochloride structure
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Common Name | Levocetirizine dihydrochloride | ||
|---|---|---|---|---|
| CAS Number | 130018-87-0 | Molecular Weight | 461.810 | |
| Density | N/A | Boiling Point | 542.1ºC at 760 mmHg | |
| Molecular Formula | C21H27Cl3N2O3 | Melting Point | 215-220ºC | |
| MSDS | Chinese USA | Flash Point | 281.6ºC | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
Use of Levocetirizine dihydrochlorideLevocetirizine dihydrochloride ((R)-Cetirizine dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Levocetirizine dihydrochloride is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine dihydrochloride has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria[1]. |
| Name | Levocetirizine Dihydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Levocetirizine dihydrochloride ((R)-Cetirizine dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Levocetirizine dihydrochloride is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine dihydrochloride has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria[1]. |
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| Related Catalog | |
| In Vivo | Levocetirizine (0.4 mg/kg; oral administration; male Sprague-Dawley rats) treatment shows that the Cmax, AUC0-t , AUC0-∞ and t1/2 are 0.34 μg/mL, 3.26 μg h/mL, 3.67 μg h/mL and 2.34 hours, respectively in Sprague-Dawley rats[1]. Animal Model: 30 male Sprague-Dawley rats (8 weeks old; 200-250 g)[1] Dosage: 0.4 mg/kg Administration: Oral administration (Pharmacokinetic Analysis) Result: The Cmax, AUC0-t , AUC0-∞ and t1/2 were 0.34 μg/mL, 3.26 μg h/mL, 3.67 μg h/mL and 2.34 hours, respectively. |
| References |
| Boiling Point | 542.1ºC at 760 mmHg |
|---|---|
| Melting Point | 215-220ºC |
| Molecular Formula | C21H27Cl3N2O3 |
| Molecular Weight | 461.810 |
| Flash Point | 281.6ºC |
| Exact Mass | 460.108734 |
| PSA | 53.01000 |
| LogP | 4.62800 |
| Storage condition | room temp |
| HS Code | 2933599090 |
|---|---|
| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Rapid chiral separation of racemic cetirizine in human plasma using subcritical fluid chromatography-tandem mass spectrometry.
J. Pharm. Biomed. Anal. 117 , 380-9, (2015) A method for fast chiral separation of cetirizine and quantitation of levocetirizine in human plasma using subcritical fluid chromatography with tandem mass spectrometry was developed and validated. T... |
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Development and characterization of pharmacokinetic parameters of fast-dissolving films containing levocetirizine.
Sci. Pharm. 80 , 779-87, (2012) A fast-dissolving film containing levocetirizine, a non-sedative antihistamine drug, was developed using pullulan, xanthan gum, propylene glycol, and tween 80 as the base materials. The drug content o... |
| Xyzall |
| EINECS 200-659-6 |
| (R)-Cetirizine Dihydrochloride |
| Levocetirizine dihydrochloride |
| (2-{4-[(R)-(4-Chlorphenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)essigsäuredihydrochlorid |
| MFCD07366507 |
| (-)-Cetirizine dihydrochloride |
| Levocetirizine 2HCl |
| Xusal |
| (2-{4-[(R)-(4-Chlorophenyl)(phenyl)methyl]-1-piperazinyl}ethoxy)acetic acid dihydrochloride |
| 2-[2-[4-[(R)-(4-Chlorophenyl)phenylmethyl]piperazin-1-yl]ethoxy]acetic Acid Dihydrochloride |
| Xyzal |
| acide (2-{4-[(R)-(4-chlorophényl)(phényl)méthyl]pipérazin-1-yl}éthoxy)acétique dichlorhydrate |
| acetic acid, [2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, dihydrochloride |
| Acetic acid, 2-[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, hydrochloride (1:2) |
| (2-{4-[(R)-(4-Chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid dihydrochloride |
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