(R)-Propranolol hydrochloride

Modify Date: 2024-01-02 09:54:46

(R)-Propranolol hydrochloride structure	Common Name	(R)-Propranolol hydrochloride
	CAS Number	13071-11-9	Molecular Weight	295.80400
	Density	N/A	Boiling Point	434.9ºC at 760 mmHg
	Molecular Formula	C₁₆H₂₂ClNO₂	Melting Point	196-198 °C(lit.)
	MSDS	Chinese USA	Flash Point	216.8ºC
	Symbol	GHS07	Signal Word	Warning

Use of (R)-Propranolol hydrochloride

(R)-Propranolol hydrochloride is a less active enantiomer of the β-adrenoceptor antagonist propranolol (HY-B0573). Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1].

Name	dexpropranolol hydrochloride
Synonym	More Synonyms

Description	(R)-Propranolol hydrochloride is a less active enantiomer of the β-adrenoceptor antagonist propranolol (HY-B0573). Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease
In Vivo	Both isomers of propranolol are capable of preventing adrenaline-induced cardiac arrhythmias in cats anaesthetized with halothane, but the mean dose of (-)-propranolol is 0.09 mg/kg whereas that of (+)-propranolol is 4.2 mg/kg[1]. Both isomers of propranolol are capable of reversing ventricular tachycardia caused by ouabain in anaesthetized cats and dogs. The dose of (-)-propranolol is significantly smaller than that of (+)-propranolol ((R)-Propranolol) in both species[1]. (R)-Propranolol hydrochloride (10 mg/kg) has no antagonistic activity in rats, the cardiac responses to isoprenaline of rat can be blocked by probably much less than 1/100th of that of the (-) isomer in this preparation[1].
References	[1]. A M Barrett,et al. The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias. Br J Pharmacol

Boiling Point	434.9ºC at 760 mmHg
Melting Point	196-198 °C(lit.)
Molecular Formula	C₁₆H₂₂ClNO₂
Molecular Weight	295.80400
Flash Point	216.8ºC
Exact Mass	295.13400
PSA	41.49000
LogP	3.77040
Vapour Pressure	2.48E-08mmHg at 25°C
Storage condition	2-8°C
Water Solubility	ethanol: 10 mg/mL

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2922509090

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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EINECS 235-961-7

MFCD00066275

(R)-(+)-PROPRANOLOL

(R)-Propranolol Hydrochloride