(S)-(-)-PROPRANOLOL HYDROCHLORIDE

Modify Date: 2024-01-05 07:09:18

(S)-(-)-PROPRANOLOL HYDROCHLORIDE Structure
(S)-(-)-PROPRANOLOL HYDROCHLORIDE structure
Common Name (S)-(-)-PROPRANOLOL HYDROCHLORIDE
CAS Number 4199-10-4 Molecular Weight 295.80400
Density N/A Boiling Point 434.9ºC at 760mmHg
Molecular Formula C16H22ClNO2 Melting Point 193-195ºC(lit.)
MSDS Chinese USA Flash Point 216.8ºC
Symbol GHS07
GHS07
Signal Word Warning

 Use of (S)-(-)-PROPRANOLOL HYDROCHLORIDE


(S)-(-)-Propranolol hydrochloride is a β-adrenergic receptor antagonist with log Kd values of -8.16, -9.08, and -6.93 for β1, β2, and β3, respectively. (S)-(-)-Propranolol hydrochloride the active enantiomer of propranolol and can be s used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[2].

 Names

Name (s)-(-)-propranolol hydrochloride
Synonym More Synonyms

 (S)-(-)-PROPRANOLOL HYDROCHLORIDE Biological Activity

Description (S)-(-)-Propranolol hydrochloride is a β-adrenergic receptor antagonist with log Kd values of -8.16, -9.08, and -6.93 for β1, β2, and β3, respectively. (S)-(-)-Propranolol hydrochloride the active enantiomer of propranolol and can be s used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[2].
Related Catalog
Target

log Kd: -8.16 (β1-adrenergic receptor) log Kd: -9.08 (β2-adrenergic receptor) log Kd: -6.93 (β3-adrenergic receptor)[1]

References

[1]. Jillian G Baker , et al. The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors. Br J Pharmacol. 2005 Feb;144(3):317-22.

 Chemical & Physical Properties

Boiling Point 434.9ºC at 760mmHg
Melting Point 193-195ºC(lit.)
Molecular Formula C16H22ClNO2
Molecular Weight 295.80400
Flash Point 216.8ºC
Exact Mass 295.13400
PSA 41.49000
LogP 3.77040
Appearance of Characters powder
Storage condition 2-8°C
Water Solubility ethanol: 10 mg/mL

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H312-H332
Precautionary Statements P280
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases R20/21/22
Safety Phrases 36
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2906199090

 Synthetic Route

 Customs

HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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 Synonyms

dl-propranololHClbp
PROPRANOLOL HCL
dl-propranolol hcl
dl-propranololhydrochloridebp
PENTAPROPANOLOLHYDROCHLORIDE
Sazetidine A dihydrochloride
DL-PROPRANOLOL HYDROCHLORIDE
EINECS 224-096-0
PROPANOLOL HYDROCHLORIDE
L-Propranololhydrochlorid
MFCD00064547
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Price: ¥1500/100 mg

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