TC-G 1006
Modify Date: 2025-08-26 21:44:45
TC-G 1006 structure
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Common Name | TC-G 1006 | ||
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| CAS Number | 1324003-64-6 | Molecular Weight | 415.36500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H16F3N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TC-G 1006S1P1 Agonist III is a potent and orally active S1P1 agonist with EC50 of 18 nM; no activity on S1P3.IC50 value: 18 nM(EC50) [1]Target: S1P1 agonistWhen dosed orally at 1 and 3 mg/kg, the azahydroxymethyl analogue 22(HY-12835) achieved statistically significant lowering of circulating blood lymphocytes 24 h postdose. In rats, a dose-proportional increase in exposure was measured when 22(HY-12835) was dosed orally at 2 and 100 mg/kg. 22 displayed excellent pharmacokinetic parameters with low clearance (CL = 0.11 L/h/kg), long mean residence time (40 h), and good oral bioavailability (F = 67%). |
| Name | 4-methoxy-N-(2-(trifluoromethyl)biphenyl-4-ylcarbamoyl)nicotinamide |
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| Synonym | More Synonyms |
| Description | S1P1 Agonist III is a potent and orally active S1P1 agonist with EC50 of 18 nM; no activity on S1P3.IC50 value: 18 nM(EC50) [1]Target: S1P1 agonistWhen dosed orally at 1 and 3 mg/kg, the azahydroxymethyl analogue 22(HY-12835) achieved statistically significant lowering of circulating blood lymphocytes 24 h postdose. In rats, a dose-proportional increase in exposure was measured when 22(HY-12835) was dosed orally at 2 and 100 mg/kg. 22 displayed excellent pharmacokinetic parameters with low clearance (CL = 0.11 L/h/kg), long mean residence time (40 h), and good oral bioavailability (F = 67%). |
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| Related Catalog | |
| References |
| Molecular Formula | C21H16F3N3O3 |
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| Molecular Weight | 415.36500 |
| Exact Mass | 415.11400 |
| PSA | 80.32000 |
| LogP | 5.20180 |
| Storage condition | 2-8℃ |
| S1P1 Agonist III |