ent-Tadalafil-d3

Modify Date: 2024-01-10 09:53:34

ent-Tadalafil-d3 structure	Common Name	ent-Tadalafil-d3
	CAS Number	1329568-92-4	Molecular Weight	392.42
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₁₆D₃N₃O₄	Melting Point	271-273 °C
	MSDS	N/A	Flash Point	N/A

Use of ent-Tadalafil-d3

ent-Tadalafil-d3 (ent-IC-351-d3) is the deuterium labeled ent-Tadalafil. ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS). compound (6R,12aS) is a potent PDE5 inhibitor with an IC50 of 0.090 μM, while ent-Tadalafil is inactive at concentrations up to 10 µM[1][2].

Name	ent-Tadalafil-d3

Description	ent-Tadalafil-d3 (ent-IC-351-d3) is the deuterium labeled ent-Tadalafil. ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS). compound (6R,12aS) is a potent PDE5 inhibitor with an IC50 of 0.090 μM, while ent-Tadalafil is inactive at concentrations up to 10 µM[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Daugan A, et al. The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues.J Med Chem. 2003 Oct 9;46(21):4533-42.

Melting Point	271-273 °C
Molecular Formula	C₂₂H₁₆D₃N₃O₄
Molecular Weight	392.42

Hazard Codes	Xi

ent-Tadalafil-d3

Use of ent-Tadalafil-d3

Names

ent-Tadalafil-d3 Biological Activity

Chemical & Physical Properties

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