ent-Tadalafil structure
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Common Name | ent-Tadalafil | ||
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CAS Number | 629652-72-8 | Molecular Weight | 389.40400 | |
Density | 1.51±0.1 g/cm3 (20 ºC 760 Torr) | Boiling Point | N/A | |
Molecular Formula | C22H19N3O4 | Melting Point | 302-304 ºC | |
MSDS | N/A | Flash Point | N/A |
Use of ent-Tadalafilent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS). compound (6R,12aS) is a potent PDE5 inhibitor with an IC50 of 0.090 μM, while ent-Tadalafil is inactive at concentrations up to 10 µM[1]. |
Name | (6S,12aS)-tadalafil |
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Synonym | More Synonyms |
Description | ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS). compound (6R,12aS) is a potent PDE5 inhibitor with an IC50 of 0.090 μM, while ent-Tadalafil is inactive at concentrations up to 10 µM[1]. |
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Related Catalog | |
Target |
PDE5:10 μM (IC50) |
References |
Density | 1.51±0.1 g/cm3 (20 ºC 760 Torr) |
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Melting Point | 302-304 ºC |
Molecular Formula | C22H19N3O4 |
Molecular Weight | 389.40400 |
Exact Mass | 389.13800 |
PSA | 74.87000 |
LogP | 2.08710 |
Water Solubility | Insuluble (8.6E-3 g/L) (25 ºC) |
~72% ent-Tadalafil CAS#:629652-72-8 |
Literature: Daugan, Alain; Grondin, Pascal; Ruault, Cecile; Le Monnier de Gouville, Anne-Charlotte; Coste, Herve; Linget, Jean Michel; Kirilovsky, Jorge; Hyafil, Francois; Labaudinieret, Richard Journal of Medicinal Chemistry, 2003 , vol. 46, # 21 p. 4533 - 4542 |
~% ent-Tadalafil CAS#:629652-72-8 |
Literature: Journal of Medicinal Chemistry, , vol. 46, # 21 p. 4533 - 4542 |
~% ent-Tadalafil CAS#:629652-72-8 |
Literature: Journal of Medicinal Chemistry, , vol. 46, # 21 p. 4533 - 4542 |
~% ent-Tadalafil CAS#:629652-72-8 |
Literature: Journal of Medicinal Chemistry, , vol. 46, # 21 p. 4533 - 4542 |
~18% ent-Tadalafil CAS#:629652-72-8 |
Literature: Bioorganic and Medicinal Chemistry, , vol. 12, # 6 p. 1505 - 1515 |
~% ent-Tadalafil CAS#:629652-72-8 |
Literature: Bioorganic and Medicinal Chemistry, , vol. 12, # 6 p. 1505 - 1515 |
~% ent-Tadalafil CAS#:629652-72-8 |
Literature: Bioorganic and Medicinal Chemistry, , vol. 12, # 6 p. 1505 - 1515 |
Precursor 8 | |
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DownStream 1 | |
L-Tildenafil |
L-Tadalafil |
ent-Tadalafil |
UNII-HZ6QJN0D4Z |
Tadalafil Impurity 12 |