Ethacrynic acid D5

Modify Date: 2024-01-07 13:14:33

Ethacrynic acid D5 structure	Common Name	Ethacrynic acid D5
	CAS Number	1330052-59-9	Molecular Weight	308.169
	Density	1.4±0.1 g/cm3	Boiling Point	480.0±45.0 °C at 760 mmHg
	Molecular Formula	C₁₃H₇D₅Cl₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	244.1±28.7 °C

Use of Ethacrynic acid D5

Ethacrynic acid D5 is a deuterium labeled Ethacrynic acid. Ethacrynic acid is a diuretic. Ethacrynic acid is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice[1][2][3][4].

Name	{2,3-Dichloro-4-[2-methylene(2H5)butanoyl]phenoxy}acetic acid
Synonym	More Synonyms

Description	Ethacrynic acid D5 is a deuterium labeled Ethacrynic acid. Ethacrynic acid is a diuretic. Ethacrynic acid is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice[1][2][3][4].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Signaling Pathways >> Metabolic Enzyme/Protease >> Gutathione S-transferase Research Areas >> Inflammation/Immunology
Target	Glutathione S-transferases (GSTs)[1]; NF-κB-signaling pathway[2]; L-type voltage-dependent and store-operated calcium channel[3]
References	[1]. Li XQ, et al. Metabolism of Strained Rings: Glutathione S-transferase-Catalyzed Formation of a Glutathione-Conjugated Spiro-azetidine without Prior Bioactivation. Drug Metab Dispos. 2019 Nov;47(11):1247-1256. [2]. Harada T, et al. Ethacrynic acid decreases expression of proinflammatory intestinal wall cytokines and ameliorates gastrointestinal stasis in murine postoperative ileus. Clinics (Sao Paulo). 2018 Oct 18;73:e332. [3]. Zhao XX, et al. Ethacrynic acid inhibits airway smooth muscle contraction in mice. Sheng Li Xue Bao. 2019 Dec 25;71(6):863-873. [4]. Byun HJ, et al. Ethacrynic Acid Inhibits Sphingosylphosphorylcholine-Induced Keratin 8 Phosphorylation and Reorganization via Transglutaminase-2 Inhibition. Biomol Ther (Seoul). 2013 Sep 30;21(5):338-42.

Density	1.4±0.1 g/cm3
Boiling Point	480.0±45.0 °C at 760 mmHg
Molecular Formula	C₁₃H₇D₅Cl₂O₄
Molecular Weight	308.169
Flash Point	244.1±28.7 °C
Exact Mass	307.042633
LogP	3.36
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.559

Hazard Codes	Xi

{2,3-Dichloro-4-[2-methylene(2H5)butanoyl]phenoxy}acetic acid

Acetic acid, 2-[2,3-dichloro-4-(2-methylene-1-oxobutyl-3,3,4,4,4-d5)phenoxy]-

DC Chemicals Limited
China
Product Name: Ethacrynic acid D5
Price:
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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