GR 73632
GR 73632 structure
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Common Name | GR 73632 | ||
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| CAS Number | 133156-06-6 | Molecular Weight | 766.00500 | |
| Density | 1.198g/cm3 | Boiling Point | 1082.2ºC at 760mmHg | |
| Molecular Formula | C40H59N7O6S | Melting Point | N/A | |
| MSDS | USA | Flash Point | 608.3ºC | |
Use of GR 73632GR-73632 is a novel tachykinin neurokinin 1 (NK-1) receptor agonist[1]. GR-73632 acts directly on the peripheral terminals of primary sensory neurons through NK1 receptor which convey itch signals[2]. |
| Name | (2S)-N-[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-1-[(2S)-2-[[(2S)-2-(5-aminopentanoylamino)-3-phenylpropanoyl]amino]-3-phenylpropanoyl]-N-methylpyrrolidine-2-carboxamide |
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| Synonym | More Synonyms |
| Description | GR-73632 is a novel tachykinin neurokinin 1 (NK-1) receptor agonist[1]. GR-73632 acts directly on the peripheral terminals of primary sensory neurons through NK1 receptor which convey itch signals[2]. |
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| Related Catalog | |
| Target |
IC50: NK-1 receptor[1] |
| References |
| Density | 1.198g/cm3 |
|---|---|
| Boiling Point | 1082.2ºC at 760mmHg |
| Molecular Formula | C40H59N7O6S |
| Molecular Weight | 766.00500 |
| Flash Point | 608.3ºC |
| Exact Mass | 765.42500 |
| PSA | 222.33000 |
| LogP | 4.66890 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.576 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Safety Phrases | S22 |
| RIDADR | NONH for all modes of transport |
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Neurokinin receptor modulation of respiratory activity in the rabbit.
Eur. J. Neurosci. 27(12) , 3233-43, (2008) The respiratory role of neurokinin (NK) receptors was investigated in alpha-chloralose-urethane-anaesthetized, vagotomized, paralysed and artificially ventilated rabbits by using bilateral microinject... |
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Phosphorylation of TRPV1 by neurokinin-1 receptor agonist exaggerates the capsaicin-mediated substance P release from cultured rat dorsal root ganglion neurons.
Neuropharmacology 55(8) , 1405-11, (2008) The present study was conducted to determine whether the activation of neurokinin-1 receptor (NK-1R) by its agonist (GR73632) enhances the capsaicin-evoked substance P (SP) release using a radioimmuno... |
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Calcitonin gene-related peptide and substance P regulate the intestinal radiation response.
Clin. Cancer Res. 12(13) , 4112-8, (2006) Intestinal toxicity is important in the therapeutic use of radiation as well as in nontherapeutic radiation exposure scenarios. Enteric sensory nerves are critical for mucosal homeostasis and for an a... |
| GR-73632 |