JNJ-42314415
Modify Date: 2024-01-31 17:51:39
JNJ-42314415 structure
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Common Name | JNJ-42314415 | ||
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| CAS Number | 1334165-90-0 | Molecular Weight | 353.418 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C19H23N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JNJ-42314415JNJ-42314415(JNJ42314415) is a potent, selective, centrally active phosphodiesterase 10A (PDE10A) inhibitor with Ki of 35 nM for human recombinant PDE10A; inhibits rPDE10A with Ki of 64 nM, >100-fold selectivity over the other 10 PDE families; blocks conditioned avoidance behavior and behaviors induced by nondopaminergic stimulants (phencyclidine, scopolamine) more efficiently than D(2) receptor blockers, with less pronounced catalepsy; shows antipsychotic activity with an improved side-effect profile in vivo. |
| Name | 3-[6-(2-Methoxyethyl)-3-pyridinyl]-2-methyl-8-(4-morpholinyl)imidazo[1,2-a]pyrazine |
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| Synonym | More Synonyms |
| Description | JNJ-42314415(JNJ42314415) is a potent, selective, centrally active phosphodiesterase 10A (PDE10A) inhibitor with Ki of 35 nM for human recombinant PDE10A; inhibits rPDE10A with Ki of 64 nM, >100-fold selectivity over the other 10 PDE families; blocks conditioned avoidance behavior and behaviors induced by nondopaminergic stimulants (phencyclidine, scopolamine) more efficiently than D(2) receptor blockers, with less pronounced catalepsy; shows antipsychotic activity with an improved side-effect profile in vivo. |
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| References | References 1. Megens AA, et al. J Pharmacol Exp Ther. 2014 Apr;349(1):138-54. View Related Products by Target Phosphodiesterase (PDE) |
| Density | 1.3±0.1 g/cm3 |
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| Molecular Formula | C19H23N5O2 |
| Molecular Weight | 353.418 |
| Exact Mass | 353.185181 |
| LogP | 0.82 |
| Index of Refraction | 1.654 |
| Imidazo[1,2-a]pyrazine, 3-[6-(2-methoxyethyl)-3-pyridinyl]-2-methyl-8-(4-morpholinyl)- |
| 3-[6-(2-Methoxyethyl)-3-pyridinyl]-2-methyl-8-(4-morpholinyl)imidazo[1,2-a]pyrazine |