Itacitinib
Modify Date: 2024-01-08 15:34:36
Itacitinib structure
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Common Name | Itacitinib | ||
|---|---|---|---|---|
| CAS Number | 1334298-90-6 | Molecular Weight | 553.51400 | |
| Density | 1.57±0.1 g/cm3(Predicted) | Boiling Point | N/A | |
| Molecular Formula | C26H23F4N9O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ItacitinibItacitinib is a potent and selective inhibitor of JAK1, with >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2; Itacitinib is used in the research of myelofibrosis. |
| Name | incb-039110 |
|---|---|
| Synonym | More Synonyms |
| Description | Itacitinib is a potent and selective inhibitor of JAK1, with >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2; Itacitinib is used in the research of myelofibrosis. |
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| Related Catalog | |
| Target |
JAK1 |
| In Vitro | Itacitinib (INCB039110) is a potent and selective inhibitor of JAK1, with >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2. Itacitinib is used in the research of myelofibrosis[1]. |
| References |
| Density | 1.57±0.1 g/cm3(Predicted) |
|---|---|
| Molecular Formula | C26H23F4N9O |
| Molecular Weight | 553.51400 |
| Exact Mass | 553.19600 |
| PSA | 119.62000 |
| LogP | 3.47948 |
| Storage condition | -20℃ |
| Hazard Codes | N |
|---|
| 2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl)piperidin-4-yl)azetidin-3-yl)acetonitrile |
| {1-{1-[3-fluoro-2-(trifluoromethyl)isonicotinoyl]piperidin-4-yl}-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile |
| {1-{1-[3-fluoro-2-(trifluoromethyl)isonicotinoyl]piperidin-4-yl}3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin3-yl}acetonitrile |
| Itacitinib |