AG 556

Modify Date: 2024-01-10 12:03:43

Use of AG 556

(E)-AG 556 is a highly selective EGFR inhibitor and also blocks LPS-induced TNF-α production[1][2].

Name	(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)-2-propenamide
Synonym	More Synonyms

Description	(E)-AG 556 is a highly selective EGFR inhibitor and also blocks LPS-induced TNF-α production[1][2].
Related Catalog	Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Research Areas >> Inflammation/Immunology
References	[1]. Gazit A, et al. Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J Med Chem. 1991 Jun;34(6):1896-907. [2]. George J, et al. Tyrphostin AG-556 reduces myocardial infarct size and improves cardiac performance in the rat. Exp Mol Pathol. 2003 Jun;74(3):314-8.

Description

(E)-AG 556 is a highly selective EGFR inhibitor and also blocks LPS-induced TNF-α production[1][2].

Related Catalog

Signaling Pathways >> JAK/STAT Signaling >> EGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

Research Areas >> Inflammation/Immunology

References

Safety Phrases	S22-S24/25

Tyrphostin B 56

AG 556

TYRPHOSTIN AG 556

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