PERK-IN-2

Modify Date: 2024-02-04 20:34:55

PERK-IN-2 Structure
PERK-IN-2 structure
Common Name PERK-IN-2
CAS Number 1337531-83-5 Molecular Weight 437.42
Density N/A Boiling Point N/A
Molecular Formula C23H18F3N5O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PERK-IN-2


PERK-IN-2 is a potent PERK inhibitor with an IC50 of 0.2 nM[1].

 Names

Name PERK-IN-2

 PERK-IN-2 Biological Activity

Description PERK-IN-2 is a potent PERK inhibitor with an IC50 of 0.2 nM[1].
Related Catalog
Target

IC50: 0.2 nM (PERK)[1]

In Vitro PERK-IN-2 (0.03-0.3 μM; 2 hours) inhibits PERK autophosphorylation in A459 cells with IC50 value ranging from 0.03−0.1 μM[1]. Cell Viability Assay[1] Cell Line: A459 cells Concentration: 0.03 μM, 0.1 μM, 0.3 μM Incubation Time: 2 hours Result: Inhibited PERK autophosphorylation in A459 cells.
References

[1]. Axten JM , et al. Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK). J Med Chem. 2012 Aug 23;55(16):7193-207.

 Chemical & Physical Properties

Molecular Formula C23H18F3N5O
Molecular Weight 437.42
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