PERK-IN-4
Modify Date: 2025-08-25 07:39:46
PERK-IN-4 structure
|
Common Name | PERK-IN-4 | ||
|---|---|---|---|---|
| CAS Number | 1337531-89-1 | Molecular Weight | 469.434 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 710.9±60.0 °C at 760 mmHg | |
| Molecular Formula | C24H19F4N5O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 383.7±32.9 °C | |
Use of PERK-IN-4PERK-IN-4 is a potent and selective PERK (protein kinase R (PKR)-like endoplasmic reticulum kinase) inhibitor with an IC 50 of 0.3 nM. PERK is activated in response to a variety of endoplasmic reticulum stresses implicated in numerous disease states[1]. |
| Name | 1-[5-(4-amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-2-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone |
|---|---|
| Synonym | More Synonyms |
| Description | PERK-IN-4 is a potent and selective PERK (protein kinase R (PKR)-like endoplasmic reticulum kinase) inhibitor with an IC 50 of 0.3 nM. PERK is activated in response to a variety of endoplasmic reticulum stresses implicated in numerous disease states[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.3 nM (PERK)[1] |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 710.9±60.0 °C at 760 mmHg |
| Molecular Formula | C24H19F4N5O |
| Molecular Weight | 469.434 |
| Flash Point | 383.7±32.9 °C |
| Exact Mass | 469.152588 |
| PSA | 77.04000 |
| LogP | 4.42 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.660 |
| Ethanone, 1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-fluoro-5-(trifluoromethyl)phenyl]- |
| 1-[5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone |
| GSK PERK Inhibitor |