INCB8761(PF-4136309)

Modify Date: 2025-08-21 17:33:59

INCB8761(PF-4136309) structure	Common Name	INCB8761(PF-4136309)
	CAS Number	1341224-83-6	Molecular Weight	568.59000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₉H₃₁F₃N₆O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of INCB8761(PF-4136309)

PF-4136309 is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50 of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2.

Name	(S)-N-[2-(3-{trans-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexylamino}pyrrolidin-1-yl)-2-oxoethyl]-3-(trifluoromethyl)benzamide
Synonym	More Synonyms

Description	PF-4136309 is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50 of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CCR Signaling Pathways >> Immunology/Inflammation >> CCR Research Areas >> Inflammation/Immunology
Target	Human CCR2:5.2 nM (IC50) Mouse CCR2:13 nM (IC50) Rat CCR2:17 nM (IC50)
In Vitro	PF-4136309 is potent in human chemotaxis activity (IC50=3.9 nM) and in the whole blood assay (IC50=19 nM), with IC50 of 16 and 2.8 nM in mouse and rat chemotaxis assays. PF-4136309 is potent in inhibiting CCR2 mediated signaling events such as intracellular calcium mobilization and ERK (extracellular signal-regulated kinase) phosphorylation with IC50 values of 3.3 and 0.5 nM, respectively. In hERG patch clamp assay, PF-4136309 inhibits hERG potassium current with an IC50 of 20 μM. PF-4136309 is not a cytochrome P450 (CYP) inhibitor, with IC50 values of >30 μM against five major CYP isozymes CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4. Moreover, PF-4136309 is not a CYP inducer at concentrations up to 30 μM[1].
In Vivo	PF-4136309 (2 mg/kg) exhibits a moderate half-life in both species after iv administration (2.5 and 2.4 h). When administered orally, PF-4136309 (10 mg/kg) is absorbed rapidly, with peak concentration time (Tmax) at 1.2 h for rats and 0.25 h for dogs. A similar half-life is observed in both species between iv dosing and po dosing. PF-4136309 is well absorbed, with an oral bioavailability of 78% in both species[1].
References	[1]. Xue CB, et al. Discovery of INCB8761/PF-4136309, a Potent, Selective, and Orally Bioavailable CCR2 Antagonist. ACS Med. Chem. Lett., 2011, 2 (12), pp 913-918.

Molecular Formula	C₂₉H₃₁F₃N₆O₃
Molecular Weight	568.59000
Exact Mass	568.24100
PSA	120.34000
LogP	4.02780
InChIKey	ZNSVOHSYDRPBGI-CBQRAPNFSA-N
SMILES	O=C(NCC(=O)N1CCC(NC2CCC(O)(c3ccc(-c4ncccn4)cn3)CC2)C1)c1cccc(C(F)(F)F)c1
Storage condition	2-8℃

4-hydroxy-4-(5-...

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Benzamide, N-[2...

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~65%

INCB8761(PF-4136309)

CAS#:1341224-83-6

Literature: Xue, Chu-Biao; Wang, Anlai; Han, Qi; Zhang, Yingxin; Cao, Ganfeng; Feng, Hao; Huang, Taisheng; Zheng, Changsheng; Xia, Michael; Zhang, Ke; Kong, Lingquan; Glenn, Joseph; Anand, Rajan; Meloni, David; Robinson; Shao, Lixin; Storace, Lou; Li, Mei; Hughes, Robert O.; Devraj, Rajesh; Morton, Philip A.; Rogier, D. Joseph; Covington, Maryanne; Scherle, Peggy; Diamond, Sharon; Emm, Tom; Yeleswaram, Swamy; Contel, Nancy; Vaddi, Kris; Newton, Robert; Hollis, Greg; Metcalf, Brian ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 12 p. 913 - 918

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INCB8761(PF-4136309)

CAS#:1341224-83-6