TAK-901-d3

Modify Date: 2024-01-06 19:12:43

TAK-901-d3 structure	Common Name	TAK-901-d3
	CAS Number	1346603-28-8	Molecular Weight	507.66
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₈H₂₉D₃N₄O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of TAK-901-d3

TAK-901-d3 is the deuterium labeled TAK-901. TAK-901 is a multi-targeted aurora inhibitor with IC50s of 21 and 15 nM for aurora A and B, respectively[1][2].

Name	TAK-901-d3

Description	TAK-901-d3 is the deuterium labeled TAK-901. TAK-901 is a multi-targeted aurora inhibitor with IC50s of 21 and 15 nM for aurora A and B, respectively[1][2].
Related Catalog	Signaling Pathways >> Epigenetics >> Aurora Kinase Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Aurora Kinase
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Farrell P, et al. Biological characterization of TAK-901, an investigational, novel, multitargeted Aurora B kinase inhibitor. Mol Cancer Ther. 2013 Apr;12(4):460-70.

Molecular Formula	C₂₈H₂₉D₃N₄O₃S
Molecular Weight	507.66

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: TAK-901-d3
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Purity: 98.0%
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