KH CB19
Modify Date: 2024-01-29 16:20:11
KH CB19 structure
|
Common Name | KH CB19 | ||
|---|---|---|---|---|
| CAS Number | 1354037-26-5 | Molecular Weight | 338.18900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H13Cl2N3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of KH CB19KH-CB19 is a potent and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4).IC50 value: 20 nM (CLK1) [1]Target: CLK1/4 inhibitorin vitro: KH-CB19 showed potent inhibition of CLK1 with an IC50 of 20 nM, and for the pure isomer KH-CB19, almost 100-fold selectivity against the CLK3 isoform. Pretreatment of cells with KH-CB19 or TG003 led to a reduction of the TNF-α-induced increase in phosphorylation of all analyzed SR proteins compared with TNF-α-stimulated controls.Treatment of resting cells with 10 μM KH-CB19 significantly reduced the basal expression of flTF as well as asHTF [1]. |
| Name | (E)-ethyl 3-(2-amino-1-cyanovinyl)-6,7-dichloro-1-methyl-1H-indole-2-carboxylate |
|---|---|
| Synonym | More Synonyms |
| Description | KH-CB19 is a potent and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4).IC50 value: 20 nM (CLK1) [1]Target: CLK1/4 inhibitorin vitro: KH-CB19 showed potent inhibition of CLK1 with an IC50 of 20 nM, and for the pure isomer KH-CB19, almost 100-fold selectivity against the CLK3 isoform. Pretreatment of cells with KH-CB19 or TG003 led to a reduction of the TNF-α-induced increase in phosphorylation of all analyzed SR proteins compared with TNF-α-stimulated controls.Treatment of resting cells with 10 μM KH-CB19 significantly reduced the basal expression of flTF as well as asHTF [1]. |
|---|---|
| Related Catalog | |
| Target |
CLK1:19.7 nM (IC50) CLK3:530 nM (IC50) DYRK1A:55.2 nM (IC50) |
| References |
[2]. Grant SK, et al. Kinase inhibition that hinges on halogen bonds. Chem Biol. 2011 Jan 28;18(1):3-4. |
| Molecular Formula | C15H13Cl2N3O2 |
|---|---|
| Molecular Weight | 338.18900 |
| Exact Mass | 337.03800 |
| PSA | 81.04000 |
| LogP | 4.18528 |
| Storage condition | 2-8℃ |
| kh-cb19 |