Chloroacetamido-PEG4-C2-Boc

Modify Date: 2024-01-08 22:11:20

Chloroacetamido-PEG4-C2-Boc Structure
Chloroacetamido-PEG4-C2-Boc structure
Common Name Chloroacetamido-PEG4-C2-Boc
CAS Number 1365655-90-8 Molecular Weight 397.892
Density 1.1±0.1 g/cm3 Boiling Point 527.7±50.0 °C at 760 mmHg
Molecular Formula C17H32ClNO7 Melting Point N/A
MSDS N/A Flash Point 272.9±30.1 °C

 Use of Chloroacetamido-PEG4-C2-Boc


Chloroacetamido-PEG4-C2-Boc is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.

 Names

Name 2-Methyl-2-propanyl 1-chloro-2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oate
Synonym More Synonyms

 Chloroacetamido-PEG4-C2-Boc Biological Activity

Description Chloroacetamido-PEG4-C2-Boc is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 527.7±50.0 °C at 760 mmHg
Molecular Formula C17H32ClNO7
Molecular Weight 397.892
Flash Point 272.9±30.1 °C
Exact Mass 397.186737
LogP -0.24
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.464
Storage condition 2-8°C

 Synonyms

6,9,12,15-Tetraoxa-3-azaoctadecan-18-oic acid, 1-chloro-2-oxo-, 1,1-dimethylethyl ester
MFCD22056319
2-Methyl-2-propanyl 1-chloro-2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oate
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