Levofloxacin hydrate

Modify Date: 2024-01-02 15:39:59

Levofloxacin hydrate Structure
Levofloxacin hydrate structure
 Common Name Levofloxacin hydrate
CAS Number 138199-71-0 Molecular Weight 370.38
Density 1.48g/cm3 Boiling Point 571.5ºC at 760mmHg
Molecular Formula C18H20FN3O4.0.5H2O Melting Point 214-216°C
MSDS N/A Flash Point N/A
Symbol GHS07 GHS08
GHS07, GHS08		 Signal Word Danger

 Use of Levofloxacin hydrate


Levofloxacin hydrate is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.Target: AntibacterialLevofloxacin reduced bacterial load compared with placebo by 4.9-fold (95% confidence interval, 1.4-25.7; P=0.02) at day 7 but had no effect at any point on any marker of neutrophilic airway inflammation. In patients with a baseline bacterial load of more than 10(6) cfu/mL, levofloxacin treatment was associated with a 26.5% (95% confidence interval, 1.8%-51.3%; P=0.04) greater reduction in the percentage neutrophil count compared with placebo at day 7 [1]. Levofloxacin was found to significantly improve the clinical and microbiological parameters in CP individuals [2]. A 30-day course of levofloxacin does not significantly improve BK viral load reduction or allograft function when used in addition to overall reduction of immunosuppression [3].

 Names

Name Levofloxacin Hemihydrate
Synonym More Synonyms

 Levofloxacin hydrate Biological Activity

Description Levofloxacin hydrate is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.Target: AntibacterialLevofloxacin reduced bacterial load compared with placebo by 4.9-fold (95% confidence interval, 1.4-25.7; P=0.02) at day 7 but had no effect at any point on any marker of neutrophilic airway inflammation. In patients with a baseline bacterial load of more than 10(6) cfu/mL, levofloxacin treatment was associated with a 26.5% (95% confidence interval, 1.8%-51.3%; P=0.04) greater reduction in the percentage neutrophil count compared with placebo at day 7 [1]. Levofloxacin was found to significantly improve the clinical and microbiological parameters in CP individuals [2]. A 30-day course of levofloxacin does not significantly improve BK viral load reduction or allograft function when used in addition to overall reduction of immunosuppression [3].
Related Catalog
References

[1]. Siva, R., et al., Effect of levofloxacin on neutrophilic airway inflammation in stable COPD: a randomized, double-blind, placebo-controlled trial. Int J Chron Obstruct Pulmon Dis, 2014. 9: p. 179-86.

[2]. Pradeep, A.R., et al., Clinical and microbiological effects of levofloxacin in the treatment of chronic periodontitis: a randomized, placebo-controlled clinical trial. J Investig Clin Dent, 2014.

[3]. Lee, B.T., et al., Efficacy of Levofloxacin in the Treatment of BK Viremia: A Multicenter, Double-Blinded, Randomized, Placebo-Controlled Trial. Clin J Am Soc Nephrol, 2014.

 Chemical & Physical Properties

Density 1.48g/cm3
Boiling Point 571.5ºC at 760mmHg
Melting Point 214-216°C
Molecular Formula C18H20FN3O4.0.5H2O
Molecular Weight 370.38
PSA 84.24000
LogP 1.48260
Vapour Pressure 6.7E-14mmHg at 25°C
Storage condition -20°C Freezer

 Safety Information

Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Danger
Hazard Statements H302-H317-H334-H361d-H362
Precautionary Statements P261-P263-P280-P342 + P311
Hazard Codes N
Risk Phrases 50/53
Safety Phrases S24/25
RIDADR NONH for all modes of transport

 Synthetic Route

methylpiperazine structure

methylpiperazine

CAS#:109-01-3

Levofloxacin carboxylic acid structure

Levofloxacin ca...

CAS#:100986-89-8

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Levofloxacin hydrate Structure

Levofloxacin hydrate

CAS#:138199-71-0

Literature: US2003/130507 A1, ;

 Precursor & DownStream

Precursor  2

DownStream  0

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 Synonyms

Levofloxacin
7H-1,4-Oxazino[2,3,4-ij]quinoline-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, (3S)-, hydrate (1:1)
(3S)-9-Fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid hydrate (1:1)
MFCD03265511
Levofloxacin hemihydrate
(S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid hydrate (2:1)
Levofloxacin hydrate
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Related Compounds: More...
Levofloxacin monohydrate
138199-72-1
Levofloxacin Hydroxy Acid
1036016-10-0
Levofloxacin N-oxide
117678-37-2
Levofloxacin dimer
2268802-22-6
Levofloxacin sodium
872606-49-0
Levofloxacin Impurity 4
2206135-16-0
Levofloxacin Impurity 18
138998-47-7
Levofloxacin carboxylic acid
100986-89-8
Levofloxacin hydrochloride
177325-13-2
3-(1-Hydroxycyclohexyl)-1-[(4-methoxyphenyl)methyl]-2-pyrrolidinone
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1178828-46-0
Rel-(1R,5R)-9-azabicyclo[3.3.1]nona-2,6-diene
1354423-12-3
1,1-Dimethylethyl 4-(aminocarbonyl)-4-[(3-methylphenyl)methyl]-1-piperidinecarboxylate
198649-41-1
N-benzyl-N-(cyanomethyl)cyclohex-3-ene-1-carboxamide
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3-[1-(5-Furan-3-yl-thiophene-2-sulfonyl)-5-methoxy-1h-indol-3-yl]-propionic acid
929251-62-7
4-(Benzyloxy)-2-(2-chloroethyl)tetrahydrofuran
1188429-46-0
3-{5-Isopropoxy-1-[4-(pyridin-4-yloxy)-benzenesulfonyl]-1h-indol-3-yl}-propionic acid
929251-15-0
3-[5-Isopropoxy-1-(2-phenoxy-benzenesulfonyl)-1h-indol-3-yl]-propionic acid
929251-26-3
3-[1-(4-Butyl-benzenesulfonyl)-6-ethoxy-1h-indol-3-yl]-propionic acid
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