Jak-in-3

Modify Date: 2025-08-23 16:56:40

Jak-in-3 Structure
Jak-in-3 structure
Common Name Jak-in-3
CAS Number 1400876-94-9 Molecular Weight 340.38
Density N/A Boiling Point N/A
Molecular Formula C18H20N4O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Jak-in-3


JAK-IN-3 (compound 22) is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively[1].

 Names

Name JAK-IN-3

 Jak-in-3 Biological Activity

Description JAK-IN-3 (compound 22) is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively[1].
Related Catalog
Target

JAK3:3 nM (IC50)

JAK1:5 nM (IC50)

Tyk2:34 nM (IC50)

JAK2:70 nM (IC50)

References

[1]. Spergel SH, et al. Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis. ACS Med Chem Lett. 2019 Feb 13;10(3):306-311.

 Chemical & Physical Properties

Molecular Formula C18H20N4O3
Molecular Weight 340.38
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