(2E)-3-(3,4-二甲氧基苯基)-N-2-噻唑基-2-丙烯酰胺

• 常用名: (2E)-3-(3,4-二甲氧基苯基)-N-2-噻唑基-2-丙烯酰胺
• 英文名: SphK1&2-IN-1
• CAS号: 1415662-57-5
• 分子量: 290.34
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₁₄N₂O₃S
• 熔点: N/A
• 闪点: N/A

用途

SphK1和2-IN-1是靶向SphK1与SphK2的SphK抑制剂。SphK1和2-IN-1具有热稳定性[1][2]。

名称

• 中文名: WAY-272077
• 英文名: 2-Propenamide, 3-(3,4-dimethoxyphenyl)-N-2-thiazolyl-, (2E)

生物活性

• 描述: SphK1和2-IN-1是靶向SphK1与SphK2的SphK抑制剂。SphK1和2-IN-1具有热稳定性[1][2]。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 心血管疾病
  研究领域 >> 炎症/免疫
  信号通路 >> 免疫及炎症 >> SPHK
• 靶点实验:

  SphK1

  SphK2

• 体外研究: SphK1和2-IN-1(化合物 40)(10μM)对 SphK1蛋白和 SphK2蛋白的抑制率分别为 14.3%和 26.5%[1]。 SphK1和2-IN-1(化合物 W4)(1-100μM)具有良好的热稳定性[1]。
• 参考文献:

  [1]. Vogt D, et al. Design, synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase inhibitors. Bioorg Med Chem. 2014 Oct 1;22(19):5354-67.

  [2]. Nong W, et al. Synthesis and biological evaluation of a new series of cinnamic acid amide derivatives as potent haemostatic agents containing a 2-aminothiazole substructure. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4506-4511.

物理化学性质

• 分子式: C₁₄H₁₄N₂O₃S
• 分子量: 290.34
• InChIKey: SMRXKMFZQYOXSX-GQCTYLIASA-N
• SMILES: COc1ccc(C=CC(=O)Nc2nccs2)cc1OC
• 储存条件: -20°C

靶点实验

查看更多实验

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实验名称：Haemostatic activity in human plasma assessed as change in rate of activated partial ... 来源：ChEMBL 靶标：Plasma External Id：CHEMBL4179004

实验名称：Inhibition of human recombinant Sphk2 at 10 uM after 60 mins by ADP2 fluorescence int... 来源：ChEMBL 靶标：Sphingosine kinase 2 External Id：CHEMBL3373185

实验名称：Haemostatic activity in human plasma assessed as change in rate of activated partial ... 来源：ChEMBL 靶标：Plasma External Id：CHEMBL4179005

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