PCPA methyl ester hydrochloride

Modify Date: 2025-08-25 15:18:15

PCPA methyl ester hydrochloride Structure
PCPA methyl ester hydrochloride structure
 Common Name PCPA methyl ester hydrochloride
CAS Number 14173-40-1 Molecular Weight 250.122
Density N/A Boiling Point 296.3ºC at 760 mmHg
Molecular Formula C10H13Cl2NO2 Melting Point 186-189 °C(lit.)
MSDS Chinese Flash Point 133ºC

 Use of PCPA methyl ester hydrochloride


PCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride), a reversible tryptophan hydroxylase inhibitor, is a serotonin (5-HT) synthesis inhibitor. PCPA methyl ester hydrochloride crosses the blood brain barrier and reduces 5-HT central availability[1][2].

 Names

Name 4-Chloro-DL-phenylalanine methyl ester hydrochloride
Synonym More Synonyms

 PCPA methyl ester hydrochloride Biological Activity

Description PCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride), a reversible tryptophan hydroxylase inhibitor, is a serotonin (5-HT) synthesis inhibitor. PCPA methyl ester hydrochloride crosses the blood brain barrier and reduces 5-HT central availability[1][2].
Related Catalog
Target

serotonin

Tryptophan Hydroxylase

In Vivo PCPA methyl ester hydrochloride (250-500 mg/kg; oral administration; daily; for 8 weeks) treatment significantly decreases serotonin levels in both hippocampus and cortex[3]. In C57BL/6 elite male mice, 5-HT levels decreased by 85% and 55% in the hippocampus of mice treated with oral or ip PCPA methyl ester hydrochloride, respectively, whereas in the prefrontal cortex, 5-HT levels decreased by 65% (oral) and 50% (ip)[3]. Animal Model: C57BL/6 elite male mice (3 months old)[3] Dosage: 500 mg/kg per day for the first 2 days and 250 mg/kg for the rest of the treatment Administration: Oral administration; daily; for 8 weeks Result: Serotonin levels were significantly decreased in both hippocampus and cortex.
References

[1]. Dool-Ri Oh, et al. Sedative and hypnotic effects of Vaccinium bracteatum Thunb. through the regulation of serotonegic and GABA A-ergic systems: Involvement of 5-HT 1A receptor agonistic activity. Biomed Pharmacother. 2019 Jan;109:2218-2227.

[2]. Fabio Bellia, et al. Transient serotonin depletion at adolescence, but not at early infancy, reduced subsequent anxiety-like behavior and alcohol intake in female mice. Psychopharmacology (Berl). 2021 Jan;238(1):215-225.

[3]. ocío B Foltran, et al. Neurochemical, Behavioral, and Neurogenic Validation of a Hyposerotonergic Animal Model by Voluntary Oral Consumption of para-Chlorophenylalanine. ACS Chem Neurosci. 2020 Mar 18;11(6):952-959.

 Chemical & Physical Properties

Boiling Point 296.3ºC at 760 mmHg
Melting Point 186-189 °C(lit.)
Molecular Formula C10H13Cl2NO2
Molecular Weight 250.122
Flash Point 133ºC
Exact Mass 249.032333
PSA 52.32000
LogP 2.88510
Storage condition −20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AY4452100
CHEMICAL NAME :
Alanine, 3-(p-chlorophenyl)-, methyl ester, hydrochloride, DL-
CAS REGISTRY NUMBER :
14173-40-1
LAST UPDATED :
198910
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C10-H12-Cl-N-O2.Cl-H
MOLECULAR WEIGHT :
250.14

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
400 mg/kg
SEX/DURATION :
male 4 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 166,1433,1969

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS AY4452100
HS Code 2922499990

 Customs

HS Code 2922499990
Summary HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

 Articles27

More Articles
Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

A test to determine the nature and presence of the memory effect columns packed with the amylose tris(3,5-dimethylphenylcarbamate) stationary phase.

J. Chromatogr. A. 1218(37) , 6302-7, (2011)

Acid/base mobile phase modifiers affect enantioseparations in ways that are not fully understood yet, for the lack of systematic studies. This makes chiral analysis of some pharmaceuticals difficult t...

AMPA glutamate receptors mediate the antidepressant-like effects of N-acetylcysteine in the mouse tail suspension test.

Behav. Pharmacol. 23(2) , 171-7, (2012)

The aim of this study was to investigate the involvement of noradrenaline, serotonin, and subtypes of glutamate receptors in the antidepressant-like effects of N-acetylcysteine (NAC). The tail suspens...

 Synonyms

4-Chloro-DL-Phe-OMe HCl
3-(4-Chlorophenyl)-1-methoxy-1-oxo-2-propanaminium chloride
Benzeneethanaminium, 4-chloro-α-(methoxycarbonyl)-, chloride (1:1)
MFCD00012530
methyl 2-amino-3-(4-chlorophenyl)propanoate,hydrochloride
DL-4-Chlorophenylalanine methyl ester hydrochloride
UNII:OC0YKX1H41
Methyl 2-amino-3-(4-chlorophenyl)propanoate hydrochloride
DL-p-Chlorophenylalanine methyl ester hydrochloride
EINECS 238-024-0
H-DL-Phe(4-Cl)-OMe.HCl
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here

Get all suppliers and price by the below link:

PCPA methyl ester hydrochloride suppliers

PCPA methyl ester hydrochloride price

Related Compounds: More...
PCPA methyl ester HCl
23434-91-5
Pregabalin methyl ester (hydrochloride)
714230-22-5
ECGONINE METHYL ESTER HYDROCHLORIDE
38969-40-3
Sarcosine methyl ester hydrochloride
1351-59-3
Benzeneethanimidicacid, methyl ester, hydrochloride (1:1)
39496-45-2
glycylphenylalanylmethionine methyl ester hydrochloride
78553-40-9
ornithine methyl ester hydrochloride
261522-14-9
BENZINIDIC ACID METHYL ESTER HYDROCHLORIDE
5873-90-5
DL-Tyrosine Methyl Ester Hydrochloride
68697-61-0
5-(Acetoxymethyl)-5-methyl-4-oxo-4,5,6,7-tetrahydrobenzofuran-3-carboxylic acid
1802180-26-2
Tert-butyl 4-(5-amino-6-ethoxypyridin-2-yl)piperidine-1-carboxylate
1802180-69-3
N-(2-(5-nitro-2H-indazol-2-yl)ethyl)methanesulfonamide
1802178-80-8
Methyl 2-(6-ethoxy-5-nitropyridin-2-yl)acetate
1802179-11-8
7-(2,5-Difluorophenyl)-4,5,6,7-tetrahydro-4-oxo-3-benzofurancarboxylic acid
1802180-79-5
Tert-butyl 4-(4-(6,6-dimethyl-4-oxo-4,5,6,7-tetrahydrobenzofuran-3-carboxamido)-3-methoxyphenyl)piperazine-1-carboxylate
1802180-13-7
Ethyl 6-ethoxy-5-nitropicolinate
1802179-85-6
4,5,6,7-Tetrahydro-6-(hydroxymethyl)-6-methyl-4-oxo-3-benzofurancarboxylic acid
1802180-23-9
Ethyl 4'-oxo-4',7'-dihydro-5'H-spiro[cyclohexane-1,6'-furo[3,2-c]pyridine]-3'-carboxylate
1802179-20-9
5-(2-(2-(Benzyloxy)ethoxy)ethyl)-4-oxo-4,5,6,7-tetrahydrofuro[3,2-c]pyridine-3-carboxylic acid
1802178-98-8
Chemsrc provides PCPA methyl ester hydrochloride(CAS#:14173-40-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of PCPA methyl ester hydrochloride are included as well.>> amp version: PCPA methyl ester hydrochloride

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved