PCPA methyl ester hydrochloride
Modify Date: 2024-01-03 11:45:43
PCPA methyl ester hydrochloride structure
|
Common Name | PCPA methyl ester hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 14173-40-1 | Molecular Weight | 250.122 | |
| Density | N/A | Boiling Point | 296.3ºC at 760 mmHg | |
| Molecular Formula | C10H13Cl2NO2 | Melting Point | 186-189 °C(lit.) | |
| MSDS | Chinese | Flash Point | 133ºC | |
Use of PCPA methyl ester hydrochloridePCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride), a reversible tryptophan hydroxylase inhibitor, is a serotonin (5-HT) synthesis inhibitor. PCPA methyl ester hydrochloride crosses the blood brain barrier and reduces 5-HT central availability[1][2]. |
| Name | 4-Chloro-DL-phenylalanine methyl ester hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | PCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride), a reversible tryptophan hydroxylase inhibitor, is a serotonin (5-HT) synthesis inhibitor. PCPA methyl ester hydrochloride crosses the blood brain barrier and reduces 5-HT central availability[1][2]. |
|---|---|
| Related Catalog | |
| Target |
serotonin Tryptophan Hydroxylase |
| In Vivo | PCPA methyl ester hydrochloride (250-500 mg/kg; oral administration; daily; for 8 weeks) treatment significantly decreases serotonin levels in both hippocampus and cortex[3]. In C57BL/6 elite male mice, 5-HT levels decreased by 85% and 55% in the hippocampus of mice treated with oral or ip PCPA methyl ester hydrochloride, respectively, whereas in the prefrontal cortex, 5-HT levels decreased by 65% (oral) and 50% (ip)[3]. Animal Model: C57BL/6 elite male mice (3 months old)[3] Dosage: 500 mg/kg per day for the first 2 days and 250 mg/kg for the rest of the treatment Administration: Oral administration; daily; for 8 weeks Result: Serotonin levels were significantly decreased in both hippocampus and cortex. |
| References |
| Boiling Point | 296.3ºC at 760 mmHg |
|---|---|
| Melting Point | 186-189 °C(lit.) |
| Molecular Formula | C10H13Cl2NO2 |
| Molecular Weight | 250.122 |
| Flash Point | 133ºC |
| Exact Mass | 249.032333 |
| PSA | 52.32000 |
| LogP | 2.88510 |
| Storage condition | −20°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
|
~%
PCPA methyl est... CAS#:14173-40-1 |
| Literature: Journal of Organic Chemistry, , vol. 61, # 19 p. 6581 - 6586 |
|
~65%
PCPA methyl est... CAS#:14173-40-1 |
| Literature: Li, Xun; Wang, Junli; Zhang, Lei; Xu, Wenfang Archiv der Pharmazie, 2011 , vol. 344, # 8 p. 494 - 504 |
|
~%
PCPA methyl est... CAS#:14173-40-1 |
| Literature: Journal of Organic Chemistry, , vol. 61, # 19 p. 6581 - 6586 |
|
~%
PCPA methyl est... CAS#:14173-40-1 |
| Literature: Journal of Peptide Science, , vol. 18, # 6 p. 418 - 426 |
CAS#:14091-08-8| HS Code | 2922499990 |
|---|---|
| Summary | HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0% |
|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc... |
|
|
A test to determine the nature and presence of the memory effect columns packed with the amylose tris(3,5-dimethylphenylcarbamate) stationary phase.
J. Chromatogr. A. 1218(37) , 6302-7, (2011) Acid/base mobile phase modifiers affect enantioseparations in ways that are not fully understood yet, for the lack of systematic studies. This makes chiral analysis of some pharmaceuticals difficult t... |
|
|
AMPA glutamate receptors mediate the antidepressant-like effects of N-acetylcysteine in the mouse tail suspension test.
Behav. Pharmacol. 23(2) , 171-7, (2012) The aim of this study was to investigate the involvement of noradrenaline, serotonin, and subtypes of glutamate receptors in the antidepressant-like effects of N-acetylcysteine (NAC). The tail suspens... |
| 4-Chloro-DL-Phe-OMe HCl |
| 3-(4-Chlorophenyl)-1-methoxy-1-oxo-2-propanaminium chloride |
| Benzeneethanaminium, 4-chloro-α-(methoxycarbonyl)-, chloride (1:1) |
| MFCD00012530 |
| methyl 2-amino-3-(4-chlorophenyl)propanoate,hydrochloride |
| DL-4-Chlorophenylalanine methyl ester hydrochloride |
| UNII:OC0YKX1H41 |
| Methyl 2-amino-3-(4-chlorophenyl)propanoate hydrochloride |
| DL-p-Chlorophenylalanine methyl ester hydrochloride |
| EINECS 238-024-0 |
| H-DL-Phe(4-Cl)-OMe.HCl |
- GL Biochem (Shanghai) Ltd.
- China
- Product Name: PCPA methyl ester hydrochloride
- Price: ￥Inquiry/1kg ￥Inquiry/1g
- Purity: 99.0%
- Stocking Period: Inquiry
- Contact: Jackie Yang
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: PCPA methyl ester hydrochloride
- Price: ￥268.0/1g ￥478.0/5g ￥1878.0/25g
- Purity: 98.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: PCPA methyl ester hydrochloride
- Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Nanjing Peptide Biotech Ltd
- China
- Product Name: H-DL-Phe(4-Cl)-OMe.HCl
- Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
- Purity: 98.0%
- Stocking Period: 7 Day
- Contact: jom
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: DL-4-Chlorophenylalanine methyl ester hydrochloride
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
Get all suppliers and price by the below link: