PCPA methyl ester hydrochloride
PCPA methyl ester hydrochloride structure
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Common Name | PCPA methyl ester hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 14173-40-1 | Molecular Weight | 250.122 | |
| Density | N/A | Boiling Point | 296.3ºC at 760 mmHg | |
| Molecular Formula | C10H13Cl2NO2 | Melting Point | 186-189 °C(lit.) | |
| MSDS | Chinese | Flash Point | 133ºC | |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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A test to determine the nature and presence of the memory effect columns packed with the amylose tris(3,5-dimethylphenylcarbamate) stationary phase.
J. Chromatogr. A. 1218(37) , 6302-7, (2011) Acid/base mobile phase modifiers affect enantioseparations in ways that are not fully understood yet, for the lack of systematic studies. This makes chiral analysis of some pharmaceuticals difficult to reproduce. Once a column has been exposed to a modifier, ... |
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AMPA glutamate receptors mediate the antidepressant-like effects of N-acetylcysteine in the mouse tail suspension test.
Behav. Pharmacol. 23(2) , 171-7, (2012) The aim of this study was to investigate the involvement of noradrenaline, serotonin, and subtypes of glutamate receptors in the antidepressant-like effects of N-acetylcysteine (NAC). The tail suspension test was used with male CF1 albino mice. D,L-α-methyl-ρ... |
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Ankle joint mobilization affects postoperative pain through peripheral and central adenosine A1 receptors.
Phys. Ther. 93(3) , 401-12, (2013) Physical therapists frequently use joint mobilization therapy techniques to treat people with musculoskeletal dysfunction and pain. Several studies suggest that endogenous adenosine may act in an analgesic fashion in various pain states.The purpose of this st... |
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Inhibition of hypothalamic nitric oxide synthase gene expression in the rat paraventricular nucleus by food deprivation is independent of serotonin depletion.
J. Neuroendocrinol. 7(11) , 861-5, (1995) We have investigated the effects of food deprivation on nitric oxide synthase (NOS) transcript levels in the rat paraventricular (PVN) and supraoptic nuclei (SON), using in situ hybridization histochemistry. Food deprivation for 48 h significantly and consist... |
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Evidence for serotonin receptor subtypes involvement in agmatine antidepressant like-effect in the mouse forced swimming test.
Brain Res. 1023(2) , 253-63, (2004) This study investigated the involvement of 5-HT(1) and 5-HT(2) receptors in the antidepressant-like effect of agmatine in the mouse forced swimming test (FST). Pretreatment with p-chlorophenylalanine methyl ester (PCPA; 100 mg/kg, intraperitoneally (i.p.), an... |
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Tiapride attenuates pain transmission through an indirect activation of central serotonergic mechanism.
J. Pharmacol. Exp. Ther. 275(1) , 23-30, (1995) Tiapride dose-dependently attenuated the biphasic nociceptive responses induced by s.c. injection of formalin to the hindpaw of mice, and its activity on the first (ED50 = 110 mg/kg p.o.) and the second (ED50 = 32.0 mg/kg p.o.) phases paralleled that on the n... |
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Specificity and efficacy of noradrenaline, serotonin depletion in discrete brain areas of Swiss mice by neurotoxins.
J. Neurosci. Methods 150(1) , 111-5, (2006) The aim of this work is to define neurotoxins doses to have efficient and specific depletion of noradrenaline (NA), serotonin (5-HT) neurotransmission in cortex, striatum, hippocampus and hypothalamus of Swiss mice after intraperitoneal administration of, res... |
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Acceleration of gastrointestinal transit by momordin Ic in mice: possible involvement of 5-hydroxytryptamine, 5-HT(2) receptors and prostaglandins.
Eur. J. Pharmacol. 392(1-2) , 71-7, (2000) Possible involvement of 5-hydroxytryptamine (5-HT), 5-HT receptors and prostaglandins in the acceleration of gastrointestinal transit by momordin Ic was investigated in mice. Accelerative effect of momordin Ic (25 mg/kg, p.o.) on gastrointestinal transit was ... |
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Serotonin and acetylcholine are crucial to maintain hippocampal synapses and memory acquisition in rats.
Neurosci. Lett. 230(1) , 13-6, (1997) Treatment with serotonin and acetylcholine depletors reduced the number of synapses in the rat hippocampus. Animals that received the drug treatment lost a substantial number of synapses and showed an apparent impairment in memory acquisition. Although the an... |