Melanin probe-1

Modify Date: 2024-01-16 14:18:10

Melanin probe-1 Structure
Melanin probe-1 structure
Common Name Melanin probe-1
CAS Number 1420844-62-7 Molecular Weight 239.29
Density N/A Boiling Point N/A
Molecular Formula C12H18FN3O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Melanin probe-1


Melanin probe-1 is an 18F-picolinamides based PET probe. Melanin probe-1 can be used for PET imaging of malignant melanoma. Melanin probe-1 exhibits high tumor targeting efficiency, excellent tumor imaging contrasts, desirable biodistribution patterns, and good in vivo stability[1].

 Names

Name Melanin probe-1

 Melanin probe-1 Biological Activity

Description Melanin probe-1 is an 18F-picolinamides based PET probe. Melanin probe-1 can be used for PET imaging of malignant melanoma. Melanin probe-1 exhibits high tumor targeting efficiency, excellent tumor imaging contrasts, desirable biodistribution patterns, and good in vivo stability[1].
Related Catalog
In Vivo Melanin probe-1 (3.7 MBq; tail vein) exhibits high tumor targeting efficiency[1]. Melanin probe-1 shows high in vivo stability and favorable pharmacokinetic properties such as fast clearance from urinal system and almost background level of uptakes for all of the major organs at 2 h. The high selectivity and specificity of Melanin probe-1, as evidenced by the high tumor-to-non tumor ratios, highlight that Melanin probe-1 PET has high potential to improve the melanoma detection[1]. Animal Model: C57BL/6 mice bearing B16F10 murine melanomas[1] Dosage: 3.7 MBq (100 μCi) Administration: Tail vein Result: The tumor uptakes of Melanin probe-1 were 12.74 ± 1.70, 16.61 ± 2.60, and 16.87 ± 1.23 %ID/g at 0.5, 1, and 2 h, respectively.
References

[1]. Liu H, et al. Development of 18F-labeled picolinamide probes for PET imaging of malignant melanoma. J Med Chem. 2013;56(3):895‐901.

 Chemical & Physical Properties

Molecular Formula C12H18FN3O
Molecular Weight 239.29
Storage condition 2-8°C
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Price: ¥1650/10 mM * 1  mL in DMSO

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