Propargyl-PEG8-SH

Modify Date: 2024-01-20 11:37:58

Propargyl-PEG8-SH Structure
Propargyl-PEG8-SH structure
Common Name Propargyl-PEG8-SH
CAS Number 1422540-92-8 Molecular Weight 424.55
Density N/A Boiling Point N/A
Molecular Formula C19H36O8S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Propargyl-PEG8-SH


Propargyl-PEG8-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Propargyl-PEG8-SH

 Propargyl-PEG8-SH Biological Activity

Description Propargyl-PEG8-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Molecular Formula C19H36O8S
Molecular Weight 424.55