Azido-PEG4-4-nitrophenyl carbonate

Modify Date: 2024-01-02 07:47:34

Azido-PEG4-4-nitrophenyl carbonate Structure
Azido-PEG4-4-nitrophenyl carbonate structure
Common Name Azido-PEG4-4-nitrophenyl carbonate
CAS Number 1422540-98-4 Molecular Weight 384.341
Density N/A Boiling Point N/A
Molecular Formula C15H20N4O8 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Azido-PEG4-4-nitrophenyl carbonate


Azido-PEG4-4-nitrophenyl carbonate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Azido-PEG4-4-nitrophenyl carbonate
Synonym More Synonyms

 Azido-PEG4-4-nitrophenyl carbonate Biological Activity

Description Azido-PEG4-4-nitrophenyl carbonate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C15H20N4O8
Molecular Weight 384.341
Exact Mass 384.128113
LogP 1.25

 Synonyms

AZIDO-PEG4-4-NITROPHENYL CARBONATE