RB-011

Modify Date: 2024-03-02 11:47:06

RB-011 Structure
RB-011 structure
Common Name RB-011
CAS Number 1425049-26-8 Molecular Weight 302.525
Density N/A Boiling Point N/A
Molecular Formula C21H36N+ Melting Point N/A
MSDS N/A Flash Point N/A

 Use of RB-011


A small molecule that disrupt 14-3-3 dimers at low micromolar concentrations and induce rapid down-regulation of Raf-MAPK and PI3K-Akt signaling in Jurkat cells; ahs ED50 of 3 uM for apoptosis induction in Jurkat cells, inhibits A549 lung cancer cell growth in vitro and in vivo; exhibits a rounded morphology similar to that of 14-3-3ζ KO dermal fibroblasts, increasing signal flux through the ROCK pathway, impairing the ECM remodeling, and accelerating wound healing.

 Names

Name RB-011

 RB-011 Biological Activity

Description A small molecule that disrupt 14-3-3 dimers at low micromolar concentrations and induce rapid down-regulation of Raf-MAPK and PI3K-Akt signaling in Jurkat cells; ahs ED50 of 3 uM for apoptosis induction in Jurkat cells, inhibits A549 lung cancer cell growth in vitro and in vivo; exhibits a rounded morphology similar to that of 14-3-3ζ KO dermal fibroblasts, increasing signal flux through the ROCK pathway, impairing the ECM remodeling, and accelerating wound healing.
References References 1. Woodcock JM, et al. Oncotarget. 2015 Jun 10;6(16):14522-36. 2. Kular J, et al. Dev Cell. 2015 Dec 21;35(6):759-74. View Related Products by Target 14-3-3 Protein

 Chemical & Physical Properties

Molecular Formula C21H36N+
Molecular Weight 302.525
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