SX 011
Modify Date: 2024-01-21 10:42:18
SX 011 structure
|
Common Name | SX 011 | ||
|---|---|---|---|---|
| CAS Number | 309913-42-6 | Molecular Weight | 483.96 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H27ClFN3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SX 011SX 011 is a p38 inhibitor with IC50s of 9 nM and 90 nM against p38α and p38β, respectively. SX 011 also inhibits JNK-2 with an IC50 of 100 nM. SX-011 is orally bioavailable[1]. |
| Name | 2-[6-chloro-5-[4-[(4-fluorophenyl)methyl]piperidine-1-carbonyl]-1-methylindol-3-yl]-N,N-dimethyl-2-oxoacetamide |
|---|---|
| Synonym | More Synonyms |
| Description | SX 011 is a p38 inhibitor with IC50s of 9 nM and 90 nM against p38α and p38β, respectively. SX 011 also inhibits JNK-2 with an IC50 of 100 nM. SX-011 is orally bioavailable[1]. |
|---|---|
| Related Catalog | |
| Target |
p38α:9 nM (IC50) p38β:90 nM (IC50) p38δ:> 300,000 nM (IC50) p38γ:> 300,000 nM (IC50) JNK2:100 nM (IC50) JNK1:> 300,000 nM (IC50) |
| In Vitro | SX-011 抑制 LPS 刺激的人外周血单个核细胞 (PBMC) TNFα 和白细胞介素-1β (IL-1β)，IC50 分别为 200 nM 和 900 nM。此外，IL-6 (IC50 250 nM) 和 IL-8 (IC50 100 nM) 在该实验中被显著抑制[2]。 |
| In Vivo | SX-011 在临床前物种中具有口服利用率 (rat, 24%; monkey, 29%; dog, 43%)，并已证明对大鼠急性和慢性炎症模型均有效。Rat t1/2 = 30 min[1][2]。 |
| References |
| Molecular Formula | C26H27ClFN3O3 |
|---|---|
| Molecular Weight | 483.96 |
| Exact Mass | 483.17200 |
| PSA | 62.62000 |
| LogP | 4.27450 |
| sx 011 |