VU 0424465
Modify Date: 2024-04-05 16:48:00
VU 0424465 structure
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Common Name | VU 0424465 | ||
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| CAS Number | 1428630-85-6 | Molecular Weight | 326.36 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 533.8±50.0 °C at 760 mmHg | |
| Molecular Formula | C19H19FN2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 276.7±30.1 °C | |
Use of VU 0424465VU0424465 is a potent and partial PAM (positive allosteric modulator)-agonist for mGlu5 mediated iCa2+ mobilization. VU0424465 exhibits high affinity at MPEP allosteric binding site, with a Ki value of 11.8 nM. VU0424465 is also a agonist for pERK1/2 in cortical neurons[1][2]. |
| Name | VU0424465 |
|---|---|
| Synonym | More Synonyms |
| Description | VU0424465 is a potent and partial PAM (positive allosteric modulator)-agonist for mGlu5 mediated iCa2+ mobilization. VU0424465 exhibits high affinity at MPEP allosteric binding site, with a Ki value of 11.8 nM. VU0424465 is also a agonist for pERK1/2 in cortical neurons[1][2]. |
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| Related Catalog | |
| Target |
mGlu5 |
| In Vitro | VU0424465 exhibits robust agonist activity and induces calcium mobilization in the absence of glutamate (EC50 = 171 ± 15 nM, maximum efficacy 65% compared to glutamate)[2]. VU0424465 potentiates glutamate-induced calcium mobilization, with EC50 of 1.5 ± 0.8 nM[2]. VU0424465 shows significant bias away from iCa2+ mobilization and toward IP1 accumulation (110-fold) and ERK1/2 phosphorylation (9-fold) in HEK293A-mGlu5-low cells[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 533.8±50.0 °C at 760 mmHg |
| Molecular Formula | C19H19FN2O2 |
| Molecular Weight | 326.36 |
| Flash Point | 276.7±30.1 °C |
| Exact Mass | 326.143066 |
| LogP | 2.95 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.594 |
| 5-[(3-Fluorophenyl)ethynyl]-N-[(2R)-3-hydroxy-3-methyl-2-butanyl]-2-pyridinecarboxamide |
| 2-Pyridinecarboxamide, 5-[2-(3-fluorophenyl)ethynyl]-N-[(1R)-2-hydroxy-1,2-dimethylpropyl]- |
| VU0424465 |