VU 0364849
Modify Date: 2024-01-14 14:33:37
VU 0364849 structure
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Common Name | VU 0364849 | ||
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| CAS Number | 1206711-14-9 | Molecular Weight | 451.520 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C27H25N5O2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of VU 0364849A potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 5.4 nM; also inhibits ALK6 (Ki<1 nM) and ALK2 (Ki=42.77 nM), little to no affinity for ALK4/5, BMPR2, AMPK etc.; blocks SMAD phosphorylation in vitro and in vivo, and enhances liver regeneration after partial hepatectomy. |
| Name | DMH2 |
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| Synonym | More Synonyms |
| Description | A potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 5.4 nM; also inhibits ALK6 (Ki<1 nM) and ALK2 (Ki=42.77 nM), little to no affinity for ALK4/5, BMPR2, AMPK etc.; blocks SMAD phosphorylation in vitro and in vivo, and enhances liver regeneration after partial hepatectomy. |
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| References | References 1. Tsugawa D, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):549-58. 2. Langenfeld E, et al. Mol Cancer. 2013 Oct 26;12(1):129. 3. Langenfeld E, et al. PLoS One. 2013 Apr 12;8(4):e61256. View Related Products by Target TGF beta Receptor (TGFBR) |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C27H25N5O2 |
| Molecular Weight | 451.520 |
| Exact Mass | 451.200836 |
| LogP | 2.09 |
| Index of Refraction | 1.689 |
| RIDADR | NONH for all modes of transport |
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Small molecule antagonist of the bone morphogenetic protein type I receptors suppresses growth and expression of Id1 and Id3 in lung cancer cells expressing Oct4 or nestin.
Mol. Cancer 12(1) , 129, (2013) Bone morphogenetic proteins (BMP) are embryonic morphogens that are aberrantly expressed in lung cancer. BMPs mediate cell fate decisions and self-renewal of stem cells, through transcription regulati... |
| DMH2 |
| 4-(6-{4-[2-(4-Morpholinyl)ethoxy]phenyl}pyrazolo[1,5-a]pyrimidin-3-yl)quinoline |
| VU0364849 |
| 4-[6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline |
| Quinoline, 4-[6-[4-[2-(4-morpholinyl)ethoxy]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]- |